3.7∣25-μg DNA vaccine patches significantly decreased the
infiltration of inflammatory cells in skin tissues with both therapeutic
and prophylactic approaches
Figure 4 depicts the pathologic changes in dermis in response
to midge allergen For t 2 challenge. In the NV-T and NV-P mice of Figure
4A and 4B, For t 2 allergen challenge significantly increased total and
eosinophil cell count compared to the NS mice. In contrast, total and
eosinophil cells infiltrations were suppressed in the SV25-T and SV25-P
groups.