Statistical analyses
Continuous variables, if normally distributed, were compared using
t-test, if not, were compared by Mann-Whitney U-test. Categorical
variables were compared using chi-square test. Spearman rank correlation
analysis was performed to determine the correlation between
concentrations and AUC0–12h. Sensitivity analysis was
used to compare the influence of covariates on variation of MPA. A
two-tailed P <0.05 was considered statistically
significant. Statistics and graphs were performed using GraphPad Prism
8.0 and R 4.0.