Statistical analyses
Continuous variables, if normally distributed, were compared using t-test, if not, were compared by Mann-Whitney U-test. Categorical variables were compared using chi-square test. Spearman rank correlation analysis was performed to determine the correlation between concentrations and AUC0–12h. Sensitivity analysis was used to compare the influence of covariates on variation of MPA. A two-tailed P <0.05 was considered statistically significant. Statistics and graphs were performed using GraphPad Prism 8.0 and R 4.0.