Discussion
Depressive and anxiety disorders are more common in women than men
(1.5-2.5 times), whereas schizophrenia was shown greater in men10. Childbirth and pregnancy are introduced as major
emotional, physical and social events in woman’s life; level of hormones
in blood and its change is one of the reasons proposed for change in
mental health of woman in pregnancy period; so it’s possible for woman
to queer to mental disorders like depression .11, 12
Studies show that covid-19 pandemic lead to increase levels of anxiety,
depression, stress, and alcohol use.13, 14 Women with
schizophrenia face a range of adverse pregnancy outcomes including
pre-eclampsia, thromboembolic disease, preterm birth and alterations in
fetal growth in compression with the general population15. Recent finding suggests no clinically considerable
raise in congenital malformations among offspring of women taking first-
or second-generation antipsychotics in pregnancy. Respiratory distress
reported in neonates who were exposed to antipsychotic drugs. However,
careful evaluation has not carried out on relative risk of
antipsychotics drugs fetal growth 16. For example,
rispeirdone from benzisoxazole derivatives is atypical antipsychotics
that first developed 1990s. Although, its safety during pregnancy has
not been established. Among different studies, only two reported case
recognized major organ malformations as consequences of rispeirdone, and
four cases reported perinatal syndromes (two premature births, one case
of a nuchal umbilical cord and a case of a behavioral
disorder)17.
Neonatal malformations from quetiapine exposures during first trimester
of pregnancy have been reported. In animal studies sertraline lead to
impaired growth of the heart. However, meaningful risk and delivery
outcomes following sertraline exposure in human researches, have not
been reported. 18 No evidence for an increase in
congenital malformations in new born exposed to benzodiazepines such as
clonazepam during the first trimester of pregnancy. 19But its effect near delivery is unclear.
Most studies related to drug safety in pregnancy have focused on the
long-term effects and therapeutic doses specifically in first trimester
of pregnancy. The effects of high doses of drugs and suicide with multi
drugs near the delivery have been less studied
This unsuccessful suicide demonstrates common psychiatric treatment for
patient may has enough promising effect; but in pandemic period can’t be
useful. This situation has huge impact on mental health, so it shows
need for intensive care for patient with psychiatric disorder.