Discussion
Depressive and anxiety disorders are more common in women than men (1.5-2.5 times), whereas schizophrenia was shown greater in men10. Childbirth and pregnancy are introduced as major emotional, physical and social events in woman’s life; level of hormones in blood and its change is one of the reasons proposed for change in mental health of woman in pregnancy period; so it’s possible for woman to queer to mental disorders like depression .11, 12
Studies show that covid-19 pandemic lead to increase levels of anxiety, depression, stress, and alcohol use.13, 14 Women with schizophrenia face a range of adverse pregnancy outcomes including pre-eclampsia, thromboembolic disease, preterm birth and alterations in fetal growth in compression with the general population15. Recent finding suggests no clinically considerable raise in congenital malformations among offspring of women taking first- or second-generation antipsychotics in pregnancy. Respiratory distress reported in neonates who were exposed to antipsychotic drugs. However, careful evaluation has not carried out on relative risk of antipsychotics drugs fetal growth 16. For example, rispeirdone from benzisoxazole derivatives is atypical antipsychotics that first developed 1990s. Although, its safety during pregnancy has not been established. Among different studies, only two reported case recognized major organ malformations as consequences of rispeirdone, and four cases reported perinatal syndromes (two premature births, one case of a nuchal umbilical cord and a case of a behavioral disorder)17.
Neonatal malformations from quetiapine exposures during first trimester of pregnancy have been reported. In animal studies sertraline lead to impaired growth of the heart. However, meaningful risk and delivery outcomes following sertraline exposure in human researches, have not been reported. 18 No evidence for an increase in congenital malformations in new born exposed to benzodiazepines such as clonazepam during the first trimester of pregnancy. 19But its effect near delivery is unclear.
Most studies related to drug safety in pregnancy have focused on the long-term effects and therapeutic doses specifically in first trimester of pregnancy. The effects of high doses of drugs and suicide with multi drugs near the delivery have been less studied
This unsuccessful suicide demonstrates common psychiatric treatment for patient may has enough promising effect; but in pandemic period can’t be useful. This situation has huge impact on mental health, so it shows need for intensive care for patient with psychiatric disorder.