Results:
A decline in neurocognitive function was identified in 73% (22/30) of
patients on POD4. Patients with postoperative leukocytosis (WBC ≥ 10.5)
had more NCD when compared to their baseline function (p=0.03). Patients
with elevated IL-8 levels at 6 hours postoperatively had a significant
decline in NCD at POD4 (p=0.04). Surprisingly, TNF-α, IL-1β, IL-2, or
IL-6 levels were not associated with NCD (p>0.3 for all).
There was no difference in neurocognitive function between patients with
elevated HbA1c levels preoperatively (p=0.973) or elevated fasting blood
glucose levels the morning of surgery (>126mg/dL, p=0.910),
or a higher maximum blood glucose levels during CPB
(>180mg/dL, p=0.252), or higher average glucose levels
during CPB (>160mg/dL, p=0.639). Human transcriptome
analysis demonstrated unique and differential patterns of gene
expression in patients depending on the presence of DM and NCD.