Figure Legends
Figure 1: 1A: Elevated levels of IL-8 at 6 hours post-op are correlated
with neurocognitive decline at postoperative day 4 (POD4, p=0.04). 1B:
Postoperative leukocytosis (WBC ≥ 10.5x103mm) was
associated with NCD at POD4 when compared to their baseline function
(p=0.03). 1C: HbA1c levels are not correlated with NCD at POD4
(p=0.973). 1D: Elevated fasting glucose levels (>126mg/dL)
are not associated with NCD at POD4 (p=0.910). 1E: Among patients with
normal HbA1c levels, elevated fasting glucose levels are also not
associated with NCD. 1F: Glucose levels during CPD are not associated
with postoperative NCD (p=0.639). NCD=neurocognitive decline,
POD4=postoperative day 4, CPD=cardiopulmonary bypass
Figure 2: Postoperative genetic regulation in patients with or without
neurocognitive decline. Patients who experienced neurocognitive decline
had an upregulation of 445 genes and a downregulation of 40 genes on
POD4.
Figure 3: Post-operative genetic regulation in patients with diabetes
with or without neurocognitive decline. Patients with diabetes who
experienced NCD at POD demonstrated upregulation of 277 genes and
downregulation of 220 genes compared to those patients with diabetes but
no neurocognitive decline.
Figure 4: Postoperative genetic regulation between patients with and
without diabetes after cardiopulmonary bypass demonstrates minimal
differences.
Figure 5: Postoperative genetic regulation in patients with
neurocognitive decline with or without diabetes. Within the subset of
patients with NCD, those with diabetes upregulated 121 genes and
downregulated 159 genes compared to patients who also had NCD but not
diabetes.