Study design and Sample
We conducted a cross-sectional study to construct the CPMs of sever CRF. The first 70% CC case data were included in the model building group (training set=196), and the last 30% CC case data were included in the validation group (validation set=88), including 284 people. The intervention study was designed as a randomized controlled trial. The subjects were randomly assigned to the experimental group (N=40) and the control group (N=38) at a ratio of 1:1 (Figure 1). The control group received routine care, while the experimental group received online 8-week MBSR (Table 1) on the basis of routine care, and patients were followed up for 3 and 6 months.
The samples of this study were all CC patients from a tertiary hospital in Shenyang. According to the sample size, the researchers continuously collected CC patients who met the standards and completed the questionnaire survey. The inclusion criteria were: (1) patients with primary CC confirmed by pathology; (2) aged over 18; (3) communicate independently and fill in questionnaires; (4) know the illness of themselves; (5) volunteer to participate in the investigation and sign the informed consent. Exclusion criteria for study subjects: (1) patients with other malignant tumors at the same time; (2) patients with a history of psychiatric diseases or mental retardation; (3) patients who have received psychotherapy or intervention within one year. Rejection criteria of study objects: (1) no outcome indicators of patients were measured at any two time points. The abscission criteria of the subjects: (1) voluntary withdrawal from the study; (2) interruption of treatment or death.