5 Conclusion
Most isolated ACCs without other underlying defects in combination can
have a relatively benign outcome[1]. However, when
complications occur, the risk of mortality increases dramatically. The
most common life-threatening complication of ACC is sagittal sinus
hemorrhage, seen as a lesion near the scalp[3].
Another potential complication of ACC includes secondary infection of
the lesion. Patients are at increased risk of developing skin infections
due to the absence or impairment of the skin’s barrier to environmental
microorganisms. If not treated properly, severe infections can develop
into meningitis. When scalp defects are large, timely surgery can help
prevent these complications. ACC patients’ skin is replaced by smooth,
gray, parchment-like tissue after healing, with no hair growth. Those
with joint deformities are prone to a disability, and those with skin
defects that cross the joints may form scar contractures that interfere
with function.
Author Contributions: YAN WU acquired, analyzed, and
interpreted data, drafted the initial manuscript and reviewed and
revised it. Jun Liu, and Qiong Luo contributed to the analysis and
interpretation of the data, contributed to drafting the manuscript, and
reviewed and revised the manuscript. All authors approved the final
manuscript as submitted and agree to be accountable for all aspects of
the work. All authors have read and agreed to the published version of
the manuscript.
Funding: No funding was secured for this study.
Informed Consent Statement: Informed consent was obtained from
all subjects involved in the
study.
Data Availability Statement: Not applicable.
Conflicts of Interest: The authors have no conflict of interest
relevant to this article to declare.
Reference:
[1] Lonie S, Phua Y, Burge J. Technique for Management of Aplasia
Cutis Congenita of the Scalp With a Skin Allograft [J]. J Craniofac
Surg. 2016,27(4):1049-1050.
[2] Southgate L, Sukalo M, Karountzos ASV, et al. Haploinsufficiency
of the NOTCH1 Receptor as a Cause of Adams-Oliver Syndrome With Variable
Cardiac Anomalies [J]. Circ Cardiovasc Genet. 2015,8(4):572-581.
[3] Saeidi M, Ehsanipoor F. A Case of Adams-Oliver Syndrome [J].
Adv Biomed Res. 2017,6:167.
[4] Rocha D, Rodrigues J, Marques JS, et al. Aplasia cutis
congenita: a conservative approach of a case with large, extensive skin,
and underlying skull defect [J]. Clinical Case Reports.
2015,3(10):841-844.
[5] Renfree KJ, Dell PC. Distal Limb Defects and Aplasia Cutis:
Adams-Oliver Syndrome [J]. J Hand Surg Am. 2016,41(7):e207-210.
[6] Belkhou A, Francois C, Bennis Y, et al. [Aplasia cutis
congenita: Update and management] [J]. Ann Chir Plast Esthet.
2016,61(5):450-461.
[7] Puvabanditsin S, February M, Garrow E, et al. Our experience
with a severe case of aplasia cutis congenita with a large skull defect
[J]. Int J Dermatol. 2016,55(10):1151-1153.
[8] Perry BM, Maughan CB, Crosby MS, et al. Aplasia cutis congenita
type V: a case report and review of the literature [J]. Int J
Dermatol. 2017,56(6):e118-e121.
[9] Miyagawa T, Kadono T, Saigusa R, et al. Multiple-opposing
rotation flaps for the scalp defect including hair whorl [J]. J
Dermatol. 2017,44(11):e302-e303.
[10] Meester JA, Southgate L, Stittrich AB, et al. Heterozygous
Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome [J].
American journal of human genetics. 2015,97(3):475-482.
[11] Gencel E, Eser C, Tabakan I, et al. Outcomes of Tissue Expander
Application for Scalp Reconstruction in Extensive Aplasia Cutis
Congenita [J]. Aesthetic Plastic Surgery. 2015,40(1):114-119.