Literature search methods:
The literature search was conducted through the China Knowledge Network Data Service and Pubmed. The keywords for the Chinese literature search were ”先天性皮肤发育不全” and ”孤立性头皮缺损”, while the keywords for the English literature search were ”aplasia cutis congenita ”and ”scalp defect”. Exclusion criteria: (1) Patients with congenital dyschondroplasia syndrome. (2) Cases with unknown diagnosis and treatment history and incomplete basic information. (3) Repeated cases reported by the same author at the same institution.
RESULTS: A total of 12 neonates with isolated scalp defects meeting the inclusion criteria were reported nationally and internationally from June 2015 to June 2020 (see Table 1). Among the twelve children, five were male. The largest scalp defect was 9.0*10.0 cm and the smallest was 0.8*1.0 cm. Two cases were treated surgically, one case was readmitted for surgery after conservative treatment due to intracranial haemorrhage in the child, and the rest were treated conservatively. All patients survived and no fatal cases were reported.