Case 1
The newborn, male, was admitted with ”scalp defect found after birth”, mother, 37 years old, father, 40 years old, G3P2, 39 weeks + 1 day of gestation, born by cesarean section due to ”scarred uterus”, birth weight 4210g, Apgar score of 9-9-9, clear amniotic fluid, 600 ml of amniotic fluid, one turn of the umbilical cord around the neck, and no abnormality of the placenta. After birth, a 3*2.5 cm scalp skin defect was found on the top of the head, and the skull was visible without bony defects, and the diagnosis was Aplasia cutis congenital. Ultrasound in early pregnancy and systemic ultrasound in mid-pregnancy showed no abnormalities, and Down’s syndrome screening in early and mid-pregnancy showed no abnormalities.Amniocentesis was recommended for ”advanced maternal age” and the karyotype and chromosome microarray of the amniotic fluid showed no abnormalities. There was no previous history of a similar disease in the child’s family, and the child’s mother had no history of specific drug exposure during pregnancy. After being informed of the condition, an emergency debridement and suture combined with local flap transfer was performed under general anesthesia with tracheal intubation. The operation was successful, and postoperative ceftizoxime sodium was used for anti-infective treatment, and wound dressing was changed. The wound was discharged on the 7th postoperative day, and the stitches were removed two weeks after surgery, and the wound healed well on the postoperative review one month later. On review three months after surgery, the child had no hair follicle growth at the original skin defect on the top of the head and was growing well. (Figure 1)