Search strategy
This systematic review and meta-analysis was carried out in accordance
with PRISMA (Preferred Reporting Items for Systematic Reviews and
Meta‐Analyses) guidelines [13]. A systematic literature search was
performed on three databases; Ovid MEDLINE(R) Epub Ahead of Print,
In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and
Ovid MEDLINE(R), (1946 to 16th September 2020), EMBASE
(1974 to 16th September 2020) and The Cochrane Central
Register of Controlled Trials (CENTRAL) databases (up to
16th September 2020). Studies which were included were
trials of diuretics used either as mono- or multi-therapy, which
examined how they affected plasma aldosterone +/- renin, serum potassium
and blood pressure. The keywords used included ‘thiazide’,
‘thiazide-like’, ‘potassium-sparing’, and ‘diuretic’. Medical subject
headings (MeSH) and non-MeSH terms were used to search the databases for
relevant publications. The full search strategy for MEDLINE is provided
in the supplementary material.