Meta-regression: Relation of change in aldosterone after diuretic to change in SBP
Random-effects meta-regression was performed to examine whether change in SBP was associated with change in PA. In the overall population, the changes in SBP were independent of changes in PA (coefficient –0.005, 95% CI –0.018, 0.009, P = 0.49, Figure 5A). However, in studies were the participants were previously untreated/washout with another antihypertensive, there was a significant relationship between the change in PA and SBP (coefficient –0.02, 95% CI –0.033, -0.01, P < 0.001, Figure 5B).