FIGURE LEGENDS
Figure 1 : PRISM diagram.
Flow-chart of included & excluded studies against a pre-defined search
criteria.
Figure 2: Forest plots displaying standardized difference in
mean PA and 95% confidence intervals. A) overall, B) previously
untreated with another antihypertensive, C) previously treated with
another antihypertensive and D) placebo. Std diff, standardised
difference; CI, confidence interval; MRA, mineralocorticoid receptor
antagonists.
Figure 3: Forest plots displaying raw difference in mean plasma
potassium and 95% confidence intervals. A) overall, B) previously
untreated with another antihypertensive, C) previously treated with
another antihypertensive and D) placebo. CI, confidence interval; MRA,
mineralocorticoid receptor antagonists.
Figure 4: Meta-regression plot of the association between mean
changes in PA with diuretic therapy and the change in serum potassium
(mEq/L) in (A) overall and (B) previously untreated with another
antihypertensive. Std diff, standardised difference.
Figure 5: Meta-regression plot of the association between mean
changes in PA with diuretic therapy and the change in SBP in (A) overall
and (B) previously untreated with another antihypertensive. SBP,
systolic blood pressure;. Std diff, standardised difference.
Figure 6. Funnel plot displaying publication bias in the
studies reporting the impact of diuretic therapy on PA change. Open
diamond represents observed effect size; closed diamond represents
imputed effect size. Std diff, standardised difference.