Search strategy
This systematic review and meta-analysis was carried out in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) guidelines [13]. A systematic literature search was performed on three databases; Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R), (1946 to 16th September 2020), EMBASE (1974 to 16th September 2020) and The Cochrane Central Register of Controlled Trials (CENTRAL) databases (up to 16th September 2020). Studies which were included were trials of diuretics used either as mono- or multi-therapy, which examined how they affected plasma aldosterone +/- renin, serum potassium and blood pressure. The keywords used included ‘thiazide’, ‘thiazide-like’, ‘potassium-sparing’, and ‘diuretic’. Medical subject headings (MeSH) and non-MeSH terms were used to search the databases for relevant publications. The full search strategy for MEDLINE is provided in the supplementary material.