FIGURE LEGENDS
Figure 1 : PRISM diagram. Flow-chart of included & excluded studies against a pre-defined search criteria.
Figure 2: Forest plots displaying standardized difference in mean PA and 95% confidence intervals. A) overall, B) previously untreated with another antihypertensive, C) previously treated with another antihypertensive and D) placebo. Std diff, standardised difference; CI, confidence interval; MRA, mineralocorticoid receptor antagonists.
Figure 3: Forest plots displaying raw difference in mean plasma potassium and 95% confidence intervals. A) overall, B) previously untreated with another antihypertensive, C) previously treated with another antihypertensive and D) placebo. CI, confidence interval; MRA, mineralocorticoid receptor antagonists.
Figure 4: Meta-regression plot of the association between mean changes in PA with diuretic therapy and the change in serum potassium (mEq/L) in (A) overall and (B) previously untreated with another antihypertensive. Std diff, standardised difference.
Figure 5: Meta-regression plot of the association between mean changes in PA with diuretic therapy and the change in SBP in (A) overall and (B) previously untreated with another antihypertensive. SBP, systolic blood pressure;. Std diff, standardised difference.
Figure 6. Funnel plot displaying publication bias in the studies reporting the impact of diuretic therapy on PA change. Open diamond represents observed effect size; closed diamond represents imputed effect size. Std diff, standardised difference.