Meta-regression: Relation of change in aldosterone after
diuretic to change in SBP
Random-effects meta-regression was performed to examine whether change
in SBP was associated with change in PA. In the overall population, the
changes in SBP were independent of changes in PA (coefficient –0.005,
95% CI –0.018, 0.009, P = 0.49, Figure 5A). However, in studies were
the participants were previously untreated/washout with another
antihypertensive, there was a significant relationship between the
change in PA and SBP (coefficient –0.02, 95% CI –0.033, -0.01, P
< 0.001, Figure 5B).