Renal and liver function test
Serum creatinine, BUN and estimated glomerular filtration rate were assessed for all patients. According to Lin et al ., a creatinine cut off normal upper level used was more than 1.2 milligrams/deciliter (mg/dL) for women and 1.4 mg/dL for men. BUN cut off level more than 23.2 mg/dL [10]. For male patients, the Glomerular filtration rate was estimated from serum creatinine concentration using the Cockroft–Gault equation, and for female; the estimated creatinine was reduced by 15%. The stages of renal dysfunction were categorized according to Ostermann and Joannidis. Patient with eGFR of ≥ 90 mL/min considered normal (stage 1), eGFR= 60-89 mL/min reflected mild kidney disease (KD), whereas, eGFR = 30-59 ml/min was subdivided into moderate stage 3A for patients with GFR = 45-59 mL/min and moderate stage 3B for patients with GFR 30-44 mL/min. reflected mild kidney disease (KD). Severe cases of KD described for patients with eGFR =15-29 mL/min, and the end-stage renal failure represents eGFR of less than 15ml/min [11].
The cut off value of abnormal liver function test used are; ALT >55 U/L, AST >48 U/L, ALP >129 U/L and total bilirubin >1.2 mg/dL [12].
The upper values of the data obtained from the recovered patients during disease period were compared to that recorded for died patients at admission (Baseline) and one day before death.