Statistical Analysis:
The results were analyzed using SPSS software (version 23.0;
SPSS, Chicago, IL, USA) and Prism 8 for OS X (version 8.4.3 GraphicPad
Software, LLC) used for figures drawing.
The continuous variables were expressed as Mean ± SD . The results
were compared using a paired student’s t-test. Median {interquartile
ranges (IQR)} was used as appropriate. The Chi-square test was used to
analyze the categorical variables, and a 95% confidence interval was
reported. The potential impact and risk of renal and hepatic injury
described by Cox hazard regression model and 95% Confidence Interval.
All statistical analysis was significant at p-value < 0.05.