Abnormal liver function test and clinical outcomes
All patient had a serial measurement of AST, ALT, ALP and total serum
bilirubin. The upper-recorded values for the recovered patients were
compared to the baseline and one day before death values for died
patients. The baseline value of total serum bilirubin was higher in died
compared to the recovered patients (Mean ± SD, 0.81 ±
0.24 versus 0.63 ± 0.36; p=0.001), whereas AST, ALT, and ALP were
not significantly differed between both group (Mean ± SD, 23.09 ±
9.69 versus 21.87 ± 12.04; p=0.436), (Mean ± SD, 29.65 ± 20.49
versus 27.46 ± 10.37; p=0.476), and (Mean ± SD, 100.85 ± 68.01
versus 104.57 ± 46.65; p=0.719), respectively (Table 4).
Comparing to recovered patients, the entire liver function test one day
before death were high in died patients {AST (Mean ± SD, 36.98 ±
10.92 versus 23.09 ± 9.69; p=0.000); ALT (Mean ± SD, 40.28 ±
12.92 versus 29.65 ± 20.49; p=0.000); ALP (Mean ± SD, 122.35 ±
40.43 versus 100.85 ± 68.01; p=0.037) and total bilirubin, (Mean
± SD, 1.36 ± 0.96 versus 0.63 ± 0.36; p=0.000)}. Furthermore,
for died patients, the AST, ALT, and total bilirubin one day before
death was significantly higher comparing to their baseline value
[AST, (Mean ± SD, 36.98 ± 10.92 versus 21.87 ± 12.04;
p=0.000); ALT (Mean ± SD, 40.28 ± 12.92 versus 27.46 ± 10.37;
p=0.000); and total bilirubin, (Mean ± SD, 1.36 ± 0.96 versus
0.81 ± 0.24; p=0.000)] (Table 4, Fig. 2).