Author, year |
Location, setting |
Study design/ Born period |
Drug
exposure measurement |
Type of neuraminidase inhibitors |
Outcome
assessment |
Outcomes |
Number of participants |
Quality |
Svensson et al, 2011 |
Sweden, population-based |
Cohort, 2005-2007 |
Swedish Prescribed
Drug Register
|
Oseltamivir or zanamivir |
Swedish
Medical
Birth Register (ICD-10)
|
Congenital
malformations, low Apgar score, SGA, low birth weight, preterm birth |
86 (exposed) 860 (no-exposed) |
8 |
Xie et al, 2013 |
Canada, population-based |
Cohort, 2009-2010 |
Better
Outcomes Registry and Network (BORN) Ontario |
Oseltamivir |
Computer
record |
SGA, preterm birth, low Apgar score |
1237 (exposed) 5,4118
(no-exposed) |
9 |
Greer et al, 2010 |
USA, hospital-based |
Cohort, 2003-2008 |
Medical
records |
Oseltamivir |
ICD-8 or ICD-10 |
Congenital malformations,
stillbirth, low birth weight |
135 (exposed) 82,097 (no-exposed) |
6 |
Graner et al, 2017 |
Denmark,
Norway,
Sweden and France, population-based
|
Cohort, 2008-2010 |
The
prescribed drug registers |
Oseltamivir or zanamivir |
ICD-10 |
Congenital malformations, low Apgar score, SGA, low birth weight,
preterm birth |
Scandinavian database 5,502 (exposed) 672,784
(no-exposed) eFeMeris database 3,22 (exposed) 19,448 (no-exposed) |
9 |
Ehrenstein et al, 2018 |
Denmark, population-based |
Cohort, 2002-2013 |
The Danish National Prescription Registry |
Oseltamivir |
Danish
National Patient Registry |
Congenital malformations, SGA, preterm birth |
1,898 (exposed) 944,278 (no-exposed) |
9 |
Chambers et al, 2019 |
United States and Canada, population-based |
Cohort, 1997-2013 |
Telephone interviews |
Oseltamivir |
Medical
records, Metropolitan Atlanta Congenital Defects Program coding system |
Congenital malformations, preterm birth, SGA |
112 (exposed) 604
(no-exposed) |
6 |
Dunstan et al, 2014 |
UK, population-based |
Cohort, 2009-2010 |
UK
Teratology Information Service |
Oseltamivir or zanamivir |
UK
Teratology Information Service, EUROCAT classification system |
Congenital malformations, low birth weight, preterm birth, |
207
(exposed) 575 (no-exposed) |
7 |
Beau et al, 2014 |
France, population-based |
Cohort, 2004-2010 |
French
prescription database |
Oseltamivir |
UK Teratology Information Service,
EUROCAT classification system |
Congenital malformations, low birth
weight, preterm birth, |
337 (exposed) 674 (no-exposed) |
8 |
Abraham et al, 2021 |
India, hospital-based |
Cohort, 2015-2017 |
Medical records |
Oseltamivir |
Medical records |
SGA, preterm birth,
low Apgar score |
174 (exposed) 302 (no-exposed) |
8 |
ICD, international Classification of diseases; SGA, small gestational
age. |
ICD, international Classification of diseases; SGA, small
gestational age. |
ICD, international Classification of diseases; SGA,
small gestational age. |
ICD, international Classification of diseases;
SGA, small gestational age. |
ICD, international Classification of
diseases; SGA, small gestational age. |
ICD, international
Classification of diseases; SGA, small gestational age. |
ICD,
international Classification of diseases; SGA, small gestational age. |
ICD, international Classification of diseases; SGA, small gestational
age. |
ICD, international Classification of diseases; SGA, small
gestational age. |