NK cells and LXA4 inhibit superoxide production
by eosinophils
As anti-inflammatory effects of LXA4 on eosinophils and
NK cells were previously reported (19), we next first determined whether
LXA4 was able to modulate eosinophil superoxide release.
Activated eosinophils significantly reduced their superoxide release in
a dose-dependent manner when exposed to LXA4 (Fig 6,A ). When eosinophils were co-incubated with NK cells in the
presence of LXA4, superoxide release was still inhibited
in a dose-dependent manner 4 hrs later (Fig 6, B ). This contrasts
with the previously observed partial activator effect of NK cells on
eosinophils (Fig 4, D ).