LXA4 is produced in the nasal mucosa after nasal allergen challenge
Quantification of LXA4 levels in nasal lavage samples showed that LXA4 was produced in the nasal mucosa at baseline and significantly increased in the nasal lavage fluid 1 hr after allergen challenge (Fig 5, A ). Increased LXA4 levels 1 hr after allergen challenge correlated with the peak of nasal neutrophil infiltration (Fig 5, B ). Interestingly, LXA4 levels also significantly increased at 48 and 72 hrs post-allergen challenge when compared to baseline levels and correlated at these time points to monocyte recruitment (Fig 5, C and D ).