Hybrid modeling
For some large target protein complexes structural templates were available only for some of the subunits or domains. In these cases, a hybrid modeling strategy was used, that is, part of the complex was modeled using comparative modeling whereas remaining subunits were docked to it either by template-based docking using TM-align24 or by free docking. In addition to that, a mixture of free docking and template-based models was submitted for several smaller targets that had templates only from structure-based search.