Children, adolescents and adults with FA and their families were observed to have low quality of life. This trial evaluated the psychosocial well-being of breastfeeding mothers having infants with FA for the first time and showed that these mothers were anxious, depressive and had many psychosocial symptoms which affected mother-to-infant bonding and interpersonal relationships. The psychosocial assessment of breastfeeding mothers with psychosocial distress is important to generate new approaches in future studies.