BAY11-7082 alters the expression of cytokines
The expression of inflammatory cytokines shapes the outcome of EAN [15]. We used the CBA to confirm the relevant changes in cytokines of EAN after treatments with BAY11-7082. That is, the expressions of TNF-α, IL-6 and IL-12 were greatly reduced in BAY11-7082 preventative group compared to control and therapeutic groups (p<0.01) (Fig. 3f). However, there were no marked differences for the expression of IL-4, IL-10, IL-1β and IL-17A among the three groups (Fig. 3f). Besides, the differences regarding the expression of cytokines that were mentioned on above in the control and therapeutic groups were meaningless.