Non-surgical treatment of a coronarography-induced iatrogenic
aortic dissection
Nicolas d’Ostrevyab, MD; Lucie
Cassagnesbc, MD, PhD ; Nicolas Durel M.D.d ; Lionel Camileriab, MD, PhD
a: Department of Cardiac Surgery, University Hospital,
Clermont- Ferrand, France.
b: T.G.I., I.P., CNRS, SIGMA, UCA, UMR 6602
c: Department of Medical Imagery, University Hospital,
Clermont- Ferrand, France
d: Pôle santé république, Clermont-Ferrand, France
Word count: 1500
Address for correspondence: Nicolas d’Ostrevy
CHU Clermont-Ferrand,
Rue Montalembert, 63 000 Clermont-Ferrand, France
Tel. +33 4 73 751 577
Fax. +33 4 73 751 579
Email:ndostrevy@chu-clermontferrand.fr
Sources of funding: None
Author contributions:
ND’O: Data collection,Concept/design, Data interpretation, Drafting
article, Approval of article
LCass: Data collection, Concept/design, Data interpretation, Critical
revision of article, Approval of article
NDu: Data collection, Other, Approval of article
LCam: Critical revision of article, Approval of article
Abstract:
Coronary dissection is an extremely rare but known complication of
coronary catheterization and angioplasty. Due to its rarity, there are
no management recommendations. However, surgery immediately after an
endovascular procedure is frequently carried out under major
antithrombotic treatment. The surgery and the postoperative consequences
are therefore very complex. We report here the documented case of a type
A aortic dissection after coronary catheterization. Despite extension to
the entire ascending aorta which indicated surgical management, the
benefit-risk balance argued for armed surveillance to avoid surgery
under antiplatelets drugs without known antidote. We believe this case
should lead us to systematically weigh the data before considering that
any iatrogenic dissection of Dunning class 3 should be operated.
Introduction:
Coronary and aortic dissection is an extremely rare but known
complication of coronary catheterization and angioplasty(1). Due to the
rarity of the event, there is no consensus on how to deal with it.
Dunning proposed in 2000 (2) a classification in 3 classes, with a
proposal for management. Class 3 represents the most important disease
with a dissection extended to more than 4 cm on the ascending aorta,
Dunning proposes that such patients should benefit from surgical
intervention because of the significant damage to the ascending aorta.
This position has since been repeated in several case report
publications (3,4). However, this management immediately after an
endovascular procedure is frequently carried out under major
antithrombotic treatment, sometimes without known antagonist treatment,
and sometimes in the immediate follow-up of an acute coronary syndrome.
The procedure and the postoperative consequences are therefore very
complex.
Case report:
We report here the case of a 68-year-old patient. Myocardial viability
assessment by dobutamine echocardiography showed an improvement in lower
hypokinesia, in favor of viability of this area. The cardiology team
therefore proposed revascularization of the coronary total occlusion
(CTO) in a double approach using LAD and the right coronary artery
(RCA). The initial examination revealed the absence of LAD restenosis.
An attempt to approach the RCA is rapidly complicated by an anterograde
and retrograde dissection of the right coronary artery and the aortic
Valsalva sinus (Fig. 1 and Video). A stenting of the RCA ostium is then
performed. After stenting, the occurrence of chest pain secondary to a
hematoma of the ascending aorta is confirmed by a computed tomography
(CT) scan (Fig. 2). The CT reveals a dissection of the ascending aorta,
extending to the thoracoabdominal traversal. This dissection involves
the supra-aortic trunks with a stenotic effect on the brachiocephalic
arterial trunk (BCAT). Acquisition synchronized to the electrocardiogram
(ECG) allow visualization of an entry tear in the RCA with retrograde
perfusion of the false channel. The extension beyond the first 4
centimeters of ascending aorta thus places the patient in Dunning 3
class. Stable hemodynamics allow the transfer of cardiac surgery to an
intensive care unit in a ”tertiary center”.
The platelet anti-aggregation by ticagrelor is interrupted and
anticoagulation to prevent thromboembolic disease in view of the
dissecting pathology is started.
In front of the iatrogenic dissection lesion, the antecedents and
particularly the ticagrelor intake, in the absence of pericardial
effusion, aortic insufficiency, organ malperfusion or any other sign of
dissection complication, it is decided in a collegial way an extremely
close surveillance.
A new imaging is performed at 24 hours and confirms the improvement with
the regression of the mass effect on the real channel (Fig. 3a). The
perfusion of the false channel from the ostium CD, visualized on the
first CT scan and absent on the next one, is still absent on this
examination.
Considering this spontaneous evolution, platelet anti-aggregation by
acetylsalicylic acid is initiated the day after admission. Preventive
anticoagulation is also started the day after admission, after evidence
of cessation of blood flow in the aortic root dissection.
Echocardiographic monitoring also confirms the absence of pericardial
effusion and good aortic valve function. We decide to continue
monitoring this iatrogenic dissection without surgical sanction. The CT
scan is repeated after 6 days and 12 Days (Fig.3b), showing regression
of the ascending aortic hematoma. She is discharged from the hospital on
day 17 and is still alive 1 year later.
Conclusions:
Ascending aortic dissection is a pathology in which, despite surgical
treatment, very high mortality and morbidity persist (2,5–7). However,
iatrogenic aortic dissection is profoundly different from idiopathic
dissection, the medianecrosis responsible for idiopathic aortic
dissection is theoretically absent in these patients who require a
coronary catheterization procedure.
We report here the case of a patient with iatrogenic aortic dissection
secondary to a CTO revascularization procedure. The recommendation
resulting from Dunning’s work (2) should have led to surgical
management. However, the use of extremely powerful antiplatelet agents,
such as ticagrelor, is becoming increasingly frequent. Although a
membranous adsorption is available (Cytosorb®), we did not have this
solution available at the time of this treatment. In the absence of a
solution to minimize the effects of taking ticagrelor, conservative
treatment was initially motivated by antiplatelet drugs intake and given
the absence of 1/significant aortic leakage 2/ pericardial effusion 3/
significant perfusion of the false channel.
Within the medical-surgical team, we decided that the balance of
benefits and risks in the initial phase of management called for
extremely close monitoring, especially since the operative mortality
reported in these iatrogenic dissections is higher than for spontaneous
dissections (5,6). We have not found in the literature any reported
cases of iatrogenic dissection of Dunning class 3 treated medically. As
predicted by Nuñez Gil (8), the spontaneous evolution is excellent,
associated with an absence of long-term recurrence (9).
We believe that in the presence of a dissection with significant
perfusion of the false channel, it would have been necessary to perform
a surgical replacement of the ascending aorta. The minimal perfusion
from a previously stented right coronary ostium allowed a conservative
treatment subject to close monitoring.
This case should lead us to systematically weigh the data before
considering that any iatrogenic dissection of Dunning class 3 should be
operated. Since this wait-and-see attitude can only be done near a
cardiac surgery department, we also advocate systematic hospitalization
in a hospital with this type of service.
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Figures:
Fig 1: angiocoronography showing dissection induced during right
coronary catheterization
Fig 2: axial (a) and multiplanar rendering (b) CT scan performed
immediately after the angiocoronarography
Fig 3: CT scan after 6 and 12 days
Video: right coronary angiography responsible for aortic dissection