Abstract:
Cytokine storm syndrome (CSS) is a serious condition induced by the
activation of cytokine cascade, characterized by systemic inflammation,
haemodynamic instability, hyperferritinaemia and multiple organ failure
(MOF). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
emerged in Wuhan China and rapidly developed into a global pandemic at
the end of 2019. This infection causes a dramatic increase of
inflammatory cytokines, suggesting the development of cytokine storm in
some critical COVID-19 patients. In our review, we summarize the
pathogenesis, clinical manifestation of CSS, and highlight the current
aspects about the recognition and diagnosis of CSS in COVID-19.