Patient Characteristics
The mean age and Body Mass Index (BMI) showed no statistical difference
between the obstructive sleep apnea patients (58.8±11 years; 29.12±5.11,
respectively) and the control group (55.06±11 years, 26.7±4.4
respectively), (p>0.05). Demographic data, blood pressure,
diabetes and lipid profile of the participants are summarized in Table
1.
Relation with DD
For DD echocardiographic parameters, OSA group had higher values in
deceleration time than the control group (10.44 ms CI [0.71,20.16];
p=0.04). Isovolumic relaxation time was statistically prolonged in OSA
group (7.85 ms CI [4.48, 11.22]; p=0.000). The ratio of early mitral
inflow velocity to mitral annular early diastolic velocity E/e’ (0.94
CI[0.44, 1.45]; p=0.000) and left atrial volume index (3.94 CI
[0.8, 7.07]; p=0.000) were significantly higher in OSA group. The
ratio of early to late mitral inflow velocities (E/A ratio) was
significantly lower in the OSA group compared to the control group
(-0.62 CI [-1,-0.24]; p=0.001). The LV mass index was also higher in
OSA group compared to control group (11.10 CI [2.56,19.65];
p=0.000). Additionally, the systolic pulmonary artery pressure (mmHg)
was significantly higher in OSA group (8.06 CI [0.94,15.17];
p=0.03). The left ventricular ejection fraction was not significantly
different between patients with OSA and controls (-0.48 CI
[-1.18,0.23]; p=0.18). Forest plots are shown in Figure 3.