Vascular endothelial markers
Treatment with sevelamer carbonate at week 12 resulted in a significant increase in ICAM-1, VCAM-1, E-selectin, and L-selectin. Treatment with calcium acetate showed a significant decrease in E-selctin levels and no change was observed with other endothelial markers. No statistical significance in the levels of P-selectin was observed in either treatment group (Table 5).
There were no significant differences observed in VCAM-1, E-selectin, and L-selectin levels between the groups (Figure 4b, 4d, and 4e). However, significant decreases in levels of ICAM-1 (**P<0.01) and P-selectin (*P <0.05) were observed when compared between treatment with calcium acetate and sevelamer carbonate (Figure 4a, 4c).