Aim
Antimicrobial resistance is an evolving phenomenon with alarming public
health consequences. Antibiotic cycling is a widely known antimicrobial
stewardship initiative which encompasses periodical shifts in empirical
treatment protocols with the aim to limit selective pressures on
bacterial populations. Nonetheless, mathematical models have challenged
its presumable efficacy by favouring a higher heterogeneity in
antibiotic administration. We present a review of the evidence regarding
the actual impact of antimicrobial cycling on bacterial resistance
control within hospitals.