Comparison SSc-all vs healthy donors (HD) Comparison SSc-all vs healthy donors (HD) Comparison SSc-all vs healthy donors (HD) Comparison SSc tadalafil/sildefanil vs SSc other drugs (OD) Comparison SSc tadalafil/sildefanil vs SSc other drugs (OD) Comparison SSc tadalafil/sildefanil vs SSc other drugs (OD)
SSc all (n. 89) HD (n. 26)
p
SSc PDE5 inhibitors (n. 8) SSc OD (81)
p
Age (years) 52.1 ± 14 49.4 ± 11 0.07 64.5 ± 14 50.3 ± 13 0.0001
Female n (%) 84 (94 %) 23 (88%) 0.37 7 (87%) 76 (93%) 0.37
Waist circumference (cm) 80.7 ± 9.5 88.4 ± 12 0.49 90 ± 5.6 79.6 ± 9.4 0.06
Hip circumference (cm) 97.5 ± 10 102.5 ± 9.9 0.15 110 ± 4.2 95.9 ±10 0.06
WHR (Waist/Hip ratio) 0.83 ± 0.7 0.86 ± 0.08 0.26 0.81 ± 0.01 0.83 ± 0.07 0,53
Body Mass Index (Kg/m2) 23.6 ± 4.2 25.13 ± 4.4 0.12 27.1 ± 5.5 23.2 ± 3.9 0.01
IL-17A 2.4 ± 6 1.7 ± 3.1 0.96 1.3 ± 2 1.8 ± 7 0.94
TNF-α 57.2 ± 62 1.0 ± 1.1 0.02 31.4 ± 60 60.4 ± 280 0.50
INF-γ 88.9 ± 172 29.6 ± 23 0.09 110 ± 175 166.1 ± 492 0.25
IL-2 42 ± 162 3.57 ± 1.3 0.01 104.5 ± 285 38 ± 149.6 0.17
IL-10 40 ± 175 4.3 ± 9.8 0.29 127.6 ± 342 33.4 ± 153.2 0.12
Leptin 15266 ± 26679 2822 ± 2045 0.00003 28353 ± 33778 11768 ± 11488 0.0001
Resistin 6146 ± 2344 1705 ± 279 0.00001 6019 ± 3211 6322 ± 2147 0.85
Visfatin 4459 ± 15177 2555 ± 12083 0.55 17732 ± 46746 3245 ± 6650 0.01
Adiponectin / 5848562 ± 6204076 6833220±5694341 0.64