Laboratory Findings
When we evaluated the laboratory parameters, the number of lymphocytes, monocytes, and platelets in the AIS group with COVID-19 was found to be significantly lower than in the non-COVID-19 AIS group (p=0.001, p=0.041, and p=0.002, respectively). Lymphopenia was detected in 53.5% (23/43) of patients with COVID-19 and thrombocytopenia in 23.3% (10/43). C-reactive protein (CRP), ferritin, D-dimer, troponin, and lactate dehydrogenase (LDH) levels were found to be significantly higher in the AIS group with COVID-19 (Table 2).
When laboratory parameters affecting mortality were examined, a statistically significant correlation was observed between the D-dimer, ferritin increase, and thrombocytopenia and mortality in the AIS group with COVID-19 (p=0.027, p=0.034, and p=0.015) (Table 3).
The values of the area under the ROC curve for the predictive values of the laboratory parameters in the dıagnosıs of COVID-19 in patıents with AIS were as follows: lymphocyte 0.772±0.05, monocyte 0.615±0.06, CRP 0.876±0.04, ferritin 0.858±0.05 , D-dimer 0.806±0.05, troponin 0.717±0.05, and LDH 0.718±0.05.
The cut-off value of 36.8 for CRP was found to have a sensitivity of 76.74% and a specificity of 90.00%; 111 for ferritin was found to have a sensitivity of 83.72% and a specificity of 75.56%; and 630 for D-dimer was found to have a sensitivity of 69.77% and a specificity of 77.78% (Table 4, Figure 3).