Association of age with AHR
In this study we found a negative association between age at time of
diagnosis and presence of AHR. Also, in multivariate analysis, age
remained a strong predictor of AHR. Our results were in accordance with
several studies that report a relationship between age and AHR in
children(14, 34, 37). But the relationship with age seems to be
multifaceted. Obviously pathophysiologic processes determining AHR alter
with age(33) as well as with the duration of disease(38), and the
predictive value of some variables changes depending on age(14). An
additional influence of age might be due to the considerable growth rate
of children leading to the application of a larger dose in young
children related to body size(34).