Table 1. Comparison of Demographic and Laboratory data according to presence of AHR
Study Population (n = 123) AHR Positive (n = 81) AHR Negative (n = 42)
p-value
Demographic data
Male sex 64 (52.0) 42 (51.9) 22 (52.4) 0.96
Age at time of diagnosis, years 10.5 (8.0-13.0) 9.7 (7.1-12.0) 12.3 (9.7-14.0) 0.001
Family history of allergic disease 38 (30.9) 24 (29.6) 14 (33.3) 0.67
Family history of asthma 18 (14.6) 12 (14.8) 6 (14.3) 0.94
Family history of hay fever 25 (20.3) 13 (16.0) 12 (28.6) 0.10
Family history of eczema 6 (4.9) 4 (4.9) 2 (4.8) 0.97
Co-existence of 2 or more atopic diseases in family 10 (8.1) 4 (4.9) 6 (14.3) 0.07
Aeroallergen sensitization 62 (50.0) 47 (58.0) 15 (35.7) 0.019
-Tree pollen 35 (28.5) 30 (37.0) 5 (11.9) 0.003
-Grass pollen 48 (39.0) 36 (44.4) 12 (28.6) 0.09
-Animal dander 26 (21.1) 22 (27.2) 4 (9.5) 0.023
-Mold 7 (5.7) 5 (6.2) 2 (4.8) 0.75
-House dust mite 45 (36.6) 36 (44.4) 9 (21.4) 0.012
Accompanying eczema 25 (20.3) 17 (21.0) 8 (19.0) 0.80
Accompanying allergic rhinitis/conjuntivitis 38 (30.9) 27 (33.3) 11 (26.2) 0.42
Pet ownership 51 (41.5) 36 (44.4) 15 (35.7) 0.35
Smoke exposition at home 13 (10.6) 10 (12.3) 3 (7.1) 0.37
Admission symptoms
Daytime cough 67 (54.5) 49 (60.5) 18 (42.9) 0.06
Nocturnal cough 29 (23.6) 25 (30.9) 4 (9.5) 0.008
Exercise-induced cough 30 (24.4) 23 (28.4) 7 (16.7) 0.15
Co-existence of nocturnal and exercise-induced cough 12 (9.8) 11 (13.6) 1 (2.4) 0.047
Dyspnea 39 (31.7) 28 (34.6) 11 (26.2) 0.34
Exercise-induced dyspnea 60 (48.8) 36 (44.4) 24 (57.1) 0.18
Daytime cough and/or dyspnea 84 (68.3) 60 (74.1) 24 (57.1) 0.06
Exercise-induced cough and/or exercise-induced dyspnea 78 (63.4) 50 (61.7) 28 (66.7) 0.59
Ever wheezing 71 (57.7) 54 (66.7) 17 (40.5) 0.005
Wheezing not associated to colds 20 (16.3) 18 (22.2) 2 (4.8) 0.013
Wheezing associated to colds 62 (50.4) 47 (58.0) 15 (35.7) 0.019
Laboratory parameters a
Peripheral blood eosinophilia count > 500/µL 19 (15.4) 18 (22.2) 1 (2.4) 0.002
Peripheral blood eosinophilia 4.0 (2.5-7.0) 5.6 (2.8-8.9) 2.8 (2.2-4.2) 0.004
Serum total IgE 123 (30-355) 150 (36-489) 77 (18-295) 0.07
Spirometry parameters
Baseline FEV1, % 100 (90-109) 100 (90-109) 101 (92-111) 0.49
Baseline FVC, % 93 (85-105) 93 (82-105) 93 (85-105) 0.84
Baseline FEV1/FVC ratio, % 100 (89-112) 100 (89-111) 102 (89-117) 0.56
Baseline FEF25, % 87 (77-98) 87 (77-95) 89 (75-99) 0.70
Baseline FEF50, % 84 (75-98) 83 (74-97) 89 (80-104) 0.13
Baseline FEF75, % 78 (64-103) 77 (61-99) 86 (69-110) 0.08
Baseline FEF25 <65% 13 (10.6) 7 (8.6) 6 (14.3) 0.33
Baseline FEF50 <65% 12 (9.8) 10 (12.3) 2 (4.8) 0.18
Baseline FEF75 <65% 31 (25.2) 25 (30.9) 6 (14.3) 0.045
Data are presented as count (%) or median (interquartile range). Abbreviations: AHR, airway hyperresponsiveness; IgE, immunoglobulin E; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; FEFxx, forced expiratory flow at XX percent of vital capacity. a Laboratory parameters were available in the study population (AHR+/AHR-) only from 80 (52/28), 93 (61/32), and 95 (62/33) children for peripheral blood eosinophilia count>500/μL), peripheral blood eosinophilia % and serum total IgE, respectively. Data are presented as count (%) or median (interquartile range). Abbreviations: AHR, airway hyperresponsiveness; IgE, immunoglobulin E; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; FEFxx, forced expiratory flow at XX percent of vital capacity. a Laboratory parameters were available in the study population (AHR+/AHR-) only from 80 (52/28), 93 (61/32), and 95 (62/33) children for peripheral blood eosinophilia count>500/μL), peripheral blood eosinophilia % and serum total IgE, respectively. Data are presented as count (%) or median (interquartile range). Abbreviations: AHR, airway hyperresponsiveness; IgE, immunoglobulin E; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; FEFxx, forced expiratory flow at XX percent of vital capacity. a Laboratory parameters were available in the study population (AHR+/AHR-) only from 80 (52/28), 93 (61/32), and 95 (62/33) children for peripheral blood eosinophilia count>500/μL), peripheral blood eosinophilia % and serum total IgE, respectively. Data are presented as count (%) or median (interquartile range). Abbreviations: AHR, airway hyperresponsiveness; IgE, immunoglobulin E; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; FEFxx, forced expiratory flow at XX percent of vital capacity. a Laboratory parameters were available in the study population (AHR+/AHR-) only from 80 (52/28), 93 (61/32), and 95 (62/33) children for peripheral blood eosinophilia count>500/μL), peripheral blood eosinophilia % and serum total IgE, respectively. Data are presented as count (%) or median (interquartile range). Abbreviations: AHR, airway hyperresponsiveness; IgE, immunoglobulin E; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; FEFxx, forced expiratory flow at XX percent of vital capacity. a Laboratory parameters were available in the study population (AHR+/AHR-) only from 80 (52/28), 93 (61/32), and 95 (62/33) children for peripheral blood eosinophilia count>500/μL), peripheral blood eosinophilia % and serum total IgE, respectively.