Impact Statement
Methacholine challenge is the most common method to detect airway hyperresponsiveness in children. However, it is time consuming and could be exhausting for patients. We aimed to develop a diagnostic tool for predicting AHR in children with respiratory symptoms without obstructive pattern. We identified tree pollen allergy, nocturnal cough, wheezing, a FEF75 < 65% and a younger age as significant predictors of AHR. This novel predictive tool might be used in children suspected of having asthma, but without an obstructive pattern, and it may decrease the need for bronchial provocation tests.