Human Cardiac Ischemia-Reperfusion Injury:
Blunted Stress Response with Age
Ashley N. Oliveira, MSc1, Bobby Yanagawa, MD,
PhD2,3, Adrian Quan, MPhil2, Subodh
Verma, MD, PhD 2,3,4 & David A. Hood,
PhD1
1Muscle Health Research Center, York University,
Toronto, ON, Canada M3J 1P3
2Division of Cardiac Surgery, Keenan Research Centre
for Biomedical Science of St. Michael’s Hospital, Toronto, ON, Canada
M5B 1W8.
Departments of 3Surgery and4Pharmacology and Toxicology, University of Toronto,
Toronto, ON, Canada M5S 1A1
Keywords: Mitochondria, mitophagy, autophagy,
ischemia-reperfusion, aging myocardium
Running Head: Mitochondria in Aged Heart
Funding: This work was supported by the Canadian Institutes for
Health and Research.
To whom correspondence should be addressed: David A. Hood, PhD
Muscle Health Research Centre,
York University, 4700 Keele St,
Toronto, ON, M3J 1P3, Canada
Tel: (416) 736-2100 ext.66640
Email: dhood@yorku.ca