Results
The present study included 155 Covid19 patients of which 78 are in the
mild, 42 are in the moderate and 35 are in the severe group.
Seventy-seven subjects were women and 78 were men enrolled in the study.
The mean (±SD) age was 52.25±17.52 in patients, and 44.60±15.52,
54.57±16.62, and 66.54±12.68 for mild, moderate, and severe groups,
respectively. The severity of the disease has increased with age
(p<0.001). Also, it was found that gender differences affect
covid19 severity and men tended to be more serious than women (p=0.003).
The percentage of males was 60% in severe groups and that is 40% for
females. The clinical signs and symptoms of the Covid19 patients are
given in Table 1.
The distribution of each genotype for ACE I/D, ACE2 rs2106809, and
rs2285666 in the Covid19 patients according to the severity of disease
are shown in Table 2. There was no statistically significant association
between groups according to genotype (p = 0.191) and allele frequencies
(p = 0.392) for ACE I/D gene polymorphism.
Because ACE2 is on the X chromosome, data for each sex were analyzed
separately in Table 2. It was also found that the distribution of
genotype and allele frequencies of ACE2 rs2106809 and rs2285666 gene
polymorphisms was similar in all groups according to the severity of
disease for both genders (p>0.05). Haplotype frequency and
association analysis were also performed (Table 3). We identified one
haplotype for two polymorphisms (rs2106809 and rs2285666) in the ACE2
receptor gene. However, no statistical difference was noted (p=0.519).
Also genotypic and allelic distribution of ACE I/D and ACE2 rs2106809
and rs2285666 polymorphisms were analyzed according to clinical symptoms
and no significant relationship was found.