Genotype and allele frequency of the polymorphism was calculated in cases according to the severity of Covid-19. The²test was used to compare genotype frequency of the ACE and ACE2 receptor gene polymorphisms in patients who have mild, moderate, or severe clinical symptoms. Because the ACE2 receptor gene is located on the X chromosome and as males are hemizygous for ACE2, males and females were analyzed separately. A p-value less than 0.05 was considered statistically significant. The software used for the calculations was SPSS version 18 (SPSS Inc., Chicago, IL).