Figure legends
Figure 1. SARS CoV-2 genome organization and mutations in
structural proteins. Frequency of mutations has been shown.
Figure 2. Stability prediction of N501Y. The mutant (Y501)
seems more stable than wild type residues (N501). The Y501 has been
detected in 4362 genome sequences, prevalent in 48 countries. The
prediction was performed through DynaMut server[16].
Figure 3. Frequency of mutations in SARS-CoV-2 spike proteins.
(A) SP: signal peptide, NTD: N-terminal domain, RBD: receptor-binding
domain, RBM: receptor binding motif, FP: fusion peptide, HR:
heptapeptide repeat sequence, TM: transmembrane region, CT: cytoplasmic
tail. S1 (14–685aa) includes, NTD (14–305aa), RBD (319–541aa), RBM
(aa437–508). S2 (686–1273aa) include FP (788–806aa), HR1
(912–984aa), HR2 (1163–1213aa), TM (1214–1237aa) and CP
(1238–1273aa) S2 subunit. (B) Domains with mutations. RBD: ACE
binding residues and mutations.
Figure 4. Domain organization of E proteins and the location
and frequency of most common mutations. TM: transmembrane, NTD:
N-terminal region, CTD: C-terminal region. (B). Pentameric
representation of E proteins and common mutation T9. (C). Full length E
protein most common mutations in the loop region.
Figure 5. D omains organization of M protein along with most
common mutations and their frequencies. (A). NTD: N-terminal region, TM:
transmembrane helices, CTD: C-terminal region. (B). Mutations most
commonly occurs at NTD and CTD.
Figure 6. Location and frequencies of some frequently occurring
mutation in N protein. (A). NTD: N-terminal domain (43-174aa),
SR-Linker: serine and arginine rich region (194-225aa), CTD: C-terminal
domain (257-364aa), RBD: RNA binding domain (40-180aa), PS:
phosphorylation sites (186, 197, 202, 204 aa). (B). Crystal structure of
NTD and most common variants.