3 | RESULTS
A total of 102 OHCA patients were included in this study. The mean age
of the study population was were 61.0 ± 12.5 and 72.5% of the patients
were male. Of these 102 patients, 59 (57.8%) died during the hospital
stay. The comparison of baseline characteristics of the survivor and
non-survivor patients are listed in Table 1. It was found that the
duration of ICU was significantly longer in survivor group compared to
non-survivor group.
Comparison of the laboratory parameters of the study population is
presented in Table 2. NLR (4.5 [3.3-5.9] vs. 2.9 [1.0-5.7], P =
0.012), CRP (6.4 [1.9-11.8] vs. 1.9 [0.8-4.5], P <
0.001), CAR (1.6 [0.5-3.3] vs. 0.5 [0.2-1.3], P <
0.001) and lactate level (7 [3.8-11.2] vs. 4.4 [2.5-7.0], P =
0.002) were significantly higher whereas lymphocyte (2.6 [1.5-3.2]
vs. 3.5 [1.9-5.8], P = 0.008) and serum albumin level (3.4 ± 0.6 vs.
3.8 ± 0.4, P < 0.001) were significantly lower in non-survivor
group.
The area under the curves (AUC) of CAR, CRP and albumin were compared
with each other to determine whether there was an additional benefit of
using CAR on CRP and albumin for predicting in-hospital mortality. The
AUC of CAR was significantly higher than both the AUC of CRP (0.738 vs
0.717, P = 002) and albumin (0.738 vs. 0.611, P < 0.001) for
predicting in-hospital mortality (Figure 1). CAR ≥ 4.6 predicted
in-hospital mortality with a sensitivity of 64.4% and specificity of
76.7%.
Multivariate logistic regression analysis was performed to determine the
independent predictors of mortality. NLR (odds ratio [OR]: 1.044,
95% confidence interval [CI]: 1.044-1.437, P = 0.013), CAR (OR:
1.971, 95% CI: 1.327-2.930, P = 0.001), and lactate level (OR: 1.268,
95% CI: 1.095-1.469, P = 0.002) were found to be the independent
predictors of mortality (Table 3).