Fig 5. The expressions of CXCL12 and CXCR4 in ovarian cancer cells after sevoflurane or propofol exposure.
SKOV3 cells were exposed to pure culture media (naïve control), 2.5% sevoflurane, or 4 μg/mL propofol for 2 hour and followed by 24 hours recovery. The expressions of CXCL12 (A) and CXCR4 (B) were detected with immunofluorescent staining (green) and overlaid with DAPI (blue). Sevoflurane exposure increased the expressions of CXCL12 and CXCR4 in ovarian cancer cells, while propofol decreased the expressions of both markers. NC: naïve control group; S: sevoflurane group; P: propofol group; CXCL12: C-X-C motif chemokine ligand 12; CXCR4: C-X-C motif chemokine receptor 4.