Diagnosis
TDT entails lifelong regular transfusion requirement for survival when the patients were confirmed diagnosed with complexed heterozygote or homozygote of β-globin gene mutations. Complete deficiency of β-globin expression is regarded as β0 and partial β-globin expression deficiency is regarded as β+. β0+, β00 and β++ are representing complexities of β0 globin genes and/or β+ globin genes.