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\begin{document}

\title{Pancreatoblastoma in children: EXPeRT/PARTNER diagnostic and therapeutic
recommendations.}



\author[1]{Ewa Bien}%
\author[2]{Jelena  Roganovic}%
\author[1]{MALGORZATA Krawczyk}%
\author[3]{Jan Godziński}%
\author[4]{Daniel Orbach}%
\author[5]{Giovanni Cecchetto}%
\author[6]{Winfred Barthlen}%
\author[7]{Anne-Sophie Defachelles}%
\author[8]{Andrea Ferrari}%
\author[9]{Christopher Weldon}%
\author[10]{Ines Brecht}%
\author[11]{Dominik T. Schneider}%
\author[12]{Gianni Bisogno}%
\author[13]{Alexandra Kolenova}%
\author[14]{Tal Ben-Ami}%
\author[15]{Kata Martinova}%
\author[5]{Calogero Virgone}%
\author[1]{Teresa Stachowicz-Stencel}%
\author[16]{Denis Kachanov}%
\author[17]{Yves Reguerre}%
\affil[1]{Medical University of Gdansk}%
\affil[2]{Clinical Hospital Center Rijeka, University of Rijeka}%
\affil[3]{Marciniak Hospital}%
\affil[4]{Institut Curie}%
\affil[5]{University of Padua}%
\affil[6]{Universitatsmedizin Greifswald}%
\affil[7]{Centre Oscar Lambret}%
\affil[8]{Istituto Nazionale Tumori, Milano }%
\affil[9]{Boston Children's Hospital, Dana-Farber Cancer Institute, \& Harvard University}%
\affil[10]{University of Tübingen}%
\affil[11]{Klinikum Dortmund}%
\affil[12]{Division of Hematology/Oncology}%
\affil[13]{Comenius University - Medical School and University Children’s Hospital}%
\affil[14]{Kaplan Medical Center}%
\affil[15]{University Clinical Centre Mother Teresa Skopje}%
\affil[16]{National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Samory Mashela str. 1, 117997}%
\affil[17]{ Felix Guyon Hospital, St Denis, La Réunion}%


\vspace{-1em}



  
  \date{May 25, 2024}


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\selectlanguage{english}
\begin{abstract}
Pancreatoblastoma (PBL) is a rare malignant epithelial neoplasm
affecting typically young children. Signs related to advanced
upper-abdominal tumor accompanied by elevated serum \selectlanguage{greek}α-\selectlanguage{english}fetoprotein levels
in a young child suggest PBL, however histopathological examination is
required for diagnosis. The mainstay of treatment is a complete surgical
resection. Inoperable and/or metastatic PBL may become amenable to
complete, delayed surgery after neo-adjuvant chemotherapy. This
manuscript presents the internationally consensus recommendations for
the diagnosis and treatment of children with PBL, established by the
European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT)
within the EU-funded PARTNER (Paediatric Rare Tumors Network -- European
Registry) project.%
\end{abstract}%



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