Pseudoaneurysm formation, a particularly dangerous complication, is
thought to result from the inflammatory reaction against BioGlue causing
altered tissue integrity.18.19 Suzuki et al suggest
that excessive BioGlue use can cause aortic wall necrosis and
pseudoaneurysm development, and indeed Luk et al. point out three cases
of pseudoaneurysm attributed to BioGlue use in aortic
surgery.1,5 Ngaage et al. note that pseudoaneurysm
formation may take up to two years following initial application of
BioGlue for type A dissection – this is particularly worrying
considering the long-term effects of BioGlue graft priming are
unknown.20