4.2.3: Pseudoaneurysm formation
Pseudoaneurysm formation, a particularly dangerous complication, is thought to result from the inflammatory reaction against BioGlue causing altered tissue integrity.18.19 Suzuki et al suggest that excessive BioGlue use can cause aortic wall necrosis and pseudoaneurysm development, and indeed Luk et al. point out three cases of pseudoaneurysm attributed to BioGlue use in aortic surgery.1,5 Ngaage et al. note that pseudoaneurysm formation may take up to two years following initial application of BioGlue for type A dissection – this is particularly worrying considering the long-term effects of BioGlue graft priming are unknown.20