Figure 2. Ventilation achieved (as % of calculated) on Visits 1 and 2 (Day 1, Day 2). A = individuals with EIB on both visits, B = individuals without EIB, C = individuals with EIB on one visit only (divergent response).
References
  1. Rabe KF, Adachi M, Lai CK, Soriano JB, Vermeire PA, Weiss KB, Weiss ST. Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol. 2004 ;114(1):40-7.
  2. Neffen H, Fritscher C, Cuevas Schacht F, Levy G, Chiarella P, Soriano JB, et al. Asthma control in Latin America: the Asthma Insights and Reality in Latin America (AIRLA) survey. Rev Panam Salud Publica. 2005;17(3):191–7.
  3. Mancuso CA, Sayles W, Robbins L, Phillips EG, Ravenell K, Duffy C, Wenderoth S, Charlson ME. Barriers and facilitators to healthy physical activity in asthma patients. J Asthma. 2006 Mar; 43(2):137-43.
  4. Velsor-Friedrich B, Vlasses F, Moberley J, Coover L. Talking with teens about asthma management. J Sch Nurs. 2004;20(3):140-148.
  5. Winn CON, Mackintosh KA, Eddolls WTB, et al. Perceptions of asthma and exercise in adolescents with and without asthma. J Asthma. 2018;55(8):868-876.
  6. Abu-Hasan M, Tannous B, Weinberger M. Exercise-induced dyspnea in children and adolescents: if not asthma then what? Ann Allergy Asthma Immunol. 2005;94(3):366-371.
  7. Depiazzi J, Everard ML. Dysfunctional breathing and reaching one’s physiological limit as causes of exercise-induced dyspnoea. Breathe (Sheff) . 2016;12(2):120-129.
  8. de Aguiar KB, Anzolin M, Zhang L. Pediatr Pulmonol. Global prevalence of exercise-induced bronchoconstriction in childhood: A meta-analysis. Pediatr Pulmonol. 2018; 53(4):412-425.
  9. Williams B, Powell A, Hoskins G, Neville R. Exploring and explaining low participation in physical activity among children and young people with asthma: a review. BMC Fam Pract. 2008;9:40. Published 2008 Jun 30.
  10. Schwartz LB, Delgado L, Craig T, et al. Exercise-induced hypersensitivity syndromes in recreational and competitive athletes: a PRACTALL consensus report (what the general practitioner should know about sports and allergy). Allergy. 2008;63(8):953-961.
  11. Hallstrand TS, Curtis JR, Koepsell TD, et al. Effectiveness of screening examinations to detect unrecognized exercise-induced bronchoconstriction. J Pediatr. 2002;141(3):343-348.
  12. Correia MA Jr, Rizzo JA, Sarinho SW, Cavalcanti Sarinho ES, Medeiros D, Assis F. Effect of exercise-induced bronchospasm and parental beliefs on physical activity of asthmatic adolescents from a tropical region. Ann Allergy Asthma Immunol. 2012;108(4):249-253.
  13. Parsons JP, Hallstrand TS, Mastronarde JG, et al. An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction. Am J Respir Crit Care Med. 2013;187(9):1016-1027.
  14. Nicolai T, Mutius EV, Reitmeir P, Wjst M. Reactivity to cold-air hyperventilation in normal and in asthmatic children in a survey of 5,697 schoolchildren in southern Bavaria. Am Rev Respir Dis. 1993;147(3):565-572.
  15. Anderson SD, Argyros GJ, Magnussen H, Holzer K. Provocation by eucapnic voluntary hyperpnoea to identify exercise induced bronchoconstriction. Br J Sports Med . 2001;35(5):344-347.
  16. Brummel NE, Mastronarde JG, Rittinger D, Philips G, Parsons JP. The clinical utility of eucapnic voluntary hyperventilation testing for the diagnosis of exercise-induced bronchospasm. J Asthma . 2009;46(7):683-686.
  17. Burman J, Elenius V, Lukkarinen H, et al. Cut-off values to evaluate exercise-induced asthma in eucapnic voluntary hyperventilation test for children [published online ahead of print, 2020 Jun 3]. Clin Physiol Funct Imaging. 2020;10.1111/cpf.12647. doi:10.1111/cpf.12647.
  18. Bartlett JW, Frost C. Reliability, repeatability and reproducibility: analysis of measurement errors in continuous variables. Ultrasound Obstet Gynecol . 2008;31(4):466-475.
  19. Anderson SD, Pearlman DS, Rundell KW, et al. Reproducibility of the airway response to an exercise protocol standardized for intensity, duration, and inspired air conditions, in subjects with symptoms suggestive of asthma. Respir Res. 2010;11(1):120. Published 2010 Sep 1.
  20. Dahlén B, O’Byrne PM, Watson RM, Roquet A, Larsen F, Inman MD. The reproducibility and sample size requirements of exercise-induced bronchoconstriction measurements. Eur Respir J . 2001;17(4):581-588.
  21. Price OJ, Ansley L, Hull JH. Diagnosing exercise-induced bronchoconstriction with eucapnic voluntary hyperpnea: is one test enough? J Allergy Clin Immunol Pract. 2015;3(2):243-249.
  22. Stadelmann K, Stensrud T, Carlsen KH. Respiratory symptoms and bronchial responsiveness in competitive swimmers. Med Sci Sports Exerc. 2011;43(3):375-381.
  23. Argyros GJ, Roach JM, Hurwitz KM, Eliasson AH, Phillips YY. Eucapnic voluntary hyperventilation as a bronchoprovocation technique: development of a standarized dosing schedule in asthmatics. Chest . 1996;109(6):1520-1524.
  24. Williams NC, Johnson MA, Hunter KA, Sharpe GR. Reproducibility of the bronchoconstrictive response to eucapnic voluntary hyperpnoea. Respir Med . 2015;109(10):1262-1267.
  25. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2018. Retrieved from http://www.ginasthma.org
  26. Roxo JP, Ponte EV, Ramos DC, Pimentel L, D’Oliveira Júnior A, Cruz AA. Validação do Teste de Controle da Asma em português para uso no Brasil: validation for use in Brazil [Portuguese-language version of the Asthma Control Test]. J Bras Pneumol. 2010;36(2):159-166.
  27. Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J . 2005;26(2):319-338.
  28. Pereira CAC, Neder JA. Sociedade Brasileira de Pneumologia. Diretrizes para Testes de Função Pulmonar. J Pneumol 2002;28(suppl. 3):1-82.
  29. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;1(8476):307-310.
  30. Winn CON, Mackintosh KA, Eddolls WTB, et al. Perceptions of asthma and exercise in adolescents with and without asthma. J Asthma. 2018;55(8):868-876.
  31. Brannan JD, Koskela H, Anderson SD. Monitoring asthma therapy using indirect bronchial provocation tests. Clin Respir J. 2007;1(1):3-15.
  32. Chateaubriand do Nascimento Silva Filho MJ, Gonçalves AV, Tavares Viana M, Peixoto DM, Cavalcanti Sarinho ES, Rizzo JÂ. Exercise-induced bronchoconstriction diagnosis in asthmatic children: comparison of treadmill running and eucapnic voluntary hyperventilation challenges. Ann Allergy Asthma Immunol. 2015;115(4):277-281
  33. Subbarao P, Duong M, Adelroth E, et al. Effect of ciclesonide dose and duration of therapy on exercise-induced bronchoconstriction in patients with asthma. J Allergy Clin Immunol. 2006;117(5):1008-1013.
  34. Brannan JD, Kippelen P. Bronchial Provocation Testing for the Identification of Exercise-Induced Bronchoconstriction. J Allergy Clin Immunol Pract . 2020;8(7):2156-2164.
  35. Weiler JM, Brannan JD, Randolph CC, et al. Exercise-induced bronchoconstriction update-2016. J Allergy Clin Immunol. 2016;138(5):1292-1295.e36.
  36. Hallstrand TS, Leuppi JD, Joos G, et al. ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing. Eur Respir J. 2018;52(5):1801033. Published 2018 Nov 15.
  37. Hurwitz KM, Argyros GJ, Roach JM, Eliasson AH, Phillips YY. Interpretation of eucapnic voluntary hyperventilation in the diagnosis of asthma. Chest. 1995;108(5):1240-1245.
  38. Hull JH, Ansley L, Price OJ, Dickinson JW, Bonini M. Eucapnic Voluntary Hyperpnea: Gold Standard for Diagnosing Exercise-Induced Bronchoconstriction in Athletes?. Sports Med . 2016;46(8):1083-1093.