Ragweed pollen allergy
Ragweed allergy dominates weed pollen allergy in North America and, after the accidental introduction of ragweed in Europe about one hundred years ago, is in continuous progression in the continent.
Major allergen Amb a 1, a pectate lyase, is a true marker of ragweed allergy and presents low cross-reactivity with related proteins from other pollen sources58. However, there is an extensive cross-reactivity among different Ambrosia species59. Currently, there are AIT products extensively documented in adults60 both in American and European patients as well as in children61 and these products are available worldwide for AIT practice.