Allergen
Sensitization rate* Available for routine CRD
Significance
Honeybee venom (Apis mellifera) Honeybee venom (Apis mellifera) Honeybee venom (Apis mellifera) Honeybee venom (Apis mellifera)
Api m 1 Phospholipase A2
57-97%
S1,2,3, M4,5,6
Marker allergen for HBV sensitization; Allows discrimination between HBV and YJV/PDV sensitization
Api m 2 Hyaluronidase
28-60%
S1,2,3, M4
Due to limited cross-reactivity with Ves v 2 and Pol d 2 in the absence of CCDs, potential marker for HBV sensitization**
Api m 3 Acid phosphatase
28-63%
S1
Marker allergen for HBV sensitization; Allows discrimination between HBV and YJV/PDV sensitization; Valuable marker allergen to diagnose HBV allergy in Api m 1-negative patients
Api m 4 Melittin
17-54%
M6
Marker allergen for HBV sensitization; Allows discrimination between HBV and YJV/PDV sensitization; Putative marker allergen for severe VIT side-effects
Api m 5 Dipeptidylpeptidase IV
16-70%
S1
High cross-reactivity with Ves v 3 and Pol d 3 prevents its use as marker allergen***
Api m 10 Icarapin
35-73%
S1,3, M4,5
Marker allergen for HBV sensitization; Allows discrimination between HBV and YJV/PDV sensitization; Valuable marker allergen to diagnose HBV allergy in Api m 1-negative patients; Dominant Api m 10 sensitization is a putative marker for risk of VIT failure
Yellow jacket venom (Vespula vulgaris) Yellow jacket venom (Vespula vulgaris) Yellow jacket venom (Vespula vulgaris) Yellow jacket venom (Vespula vulgaris)
Ves v 1 Phospholipase A1
39-66%
S1, M4,5
Marker allergen for YJV sensitization; Allows discrimination between YJV and HBV sensitization; High cross-reactivity with Pol d 1prevents its use as marker allergen to discriminate between YJV and PDV sensitization
Ves v 5 Antigen 5
82-98%
S1,2,3, M4,5
Marker allergen for YJV sensitization; Allows discrimination between YJV and HBV sensitization; High cross-reactivity with Pol d 5 prevents its use as marker allergen to discriminate between YJV and PDV sensitization
European paper wasp venom (Polistes dominula) European paper wasp venom (Polistes dominula) European paper wasp venom (Polistes dominula) European paper wasp venom (Polistes dominula)
Pol d 1 Phospholipase A1
87%
M4
Marker allergen for PDV sensitization; Allows discrimination between PDV and HBV sensitization; High cross-reactivity with Ves v 1 prevents its use as marker allergen to discriminate between PDV and YJV sensitization
Pol d 5 Antigen 5
72%
S1, M4,5
Marker allergen for PDV sensitization; Allows discrimination between PDV and HBV sensitization; High cross-reactivity with Ves v 5 prevents its use as marker allergen to discriminate between PDV and YJV sensitization