Cypress/cedar allergy
Japanese cedar pollen is the main cause for seasonal respiratory allergy
in Japan and Cupressaceae are relevant allergens in the US and southern
Europe as well. Major allergens belonging to the pectate lyase family
(Cup a 1, Cup s 1, Jun a 1 and Cry j 1) show a very high
cross-reactivity.
There is only one AIT product56,57with clinically documented efficacy. The recent registration of a
Japanese cedar vaccine in Japan opens the possibility − as in the case
of birch/oak vaccines − to explore its value for treating cedar/cypress
allergy worldwide.