Cypress/cedar allergy
Japanese cedar pollen is the main cause for seasonal respiratory allergy in Japan and Cupressaceae are relevant allergens in the US and southern Europe as well. Major allergens belonging to the pectate lyase family (Cup a 1, Cup s 1, Jun a 1 and Cry j 1) show a very high cross-reactivity.
There is only one AIT product56,57with clinically documented efficacy. The recent registration of a Japanese cedar vaccine in Japan opens the possibility − as in the case of birch/oak vaccines − to explore its value for treating cedar/cypress allergy worldwide.