Figure 6. Intratracheal delivery of BW-031 under isoflurane
anesthesia inhibits citric acid- evoked cough in guinea pigs.
a , Experimental design. BW-031 (0.23, 0.75 or 7.53 mg/kg) was
delivered intratracheally to guinea pigs under isoflurane anesthesia.
One hour later, the animals inhaled an aerosol with 400 mM citric acid
for 7 minutes (yellow) and coughs were measured over 17 minutes during
and after the citric acid challenge. b , Dose-dependent effect
of intratracheal BW-031 on citric acid-evoked cough. N=9 female guinea
pigs per group, 1-way ANOVA [F(3, 32)=5.03], p=0.0057, Tukey’s
post-hoc, *p<0.05, **p<0.01. Bars represent mean±SEM
for each condition, while the individual data points are displayed as
open circles.