Limitations:
This single-centre study has several limitations. It was performed with
limited sample size and short FU duration. Echocardiographic analyses
were not performed or validated by an independent core lab. Invasive
assessment of the left atrial pressure or exercise echocardiography was
not done. Further evaluation of the impact of MG on outcomes according
to the aetiology of MR (FMR vs DMR) was not possible owing to the too
low number of patients with elevated MG. To validate the predictive
value of parameters for adverse outcomes and unfavourable MG
appropriately powered multicentric studies with a larger patient cohort,
a longer FU and subgroup and multivariate analysis according to cut-off
values and/or propensity matching, are required.