Statistical Analyses
All quantitative results were expressed as mean ± standard error of the mean (SEM). Collected data were analyzed statistically using SPSS (version 17) using a one-way ANOVA and the Tukey’s post hoc testing for subsequent pair-wise comparisons. Data were checked prior to performing statistical tests for both normality (Shapiro-Wilk) and equal-variance (Levene’s). Spearman rank correlation analysis was used to determine potential correlations between metabolites and PHD2 activity. Significance for all tests was associated with p -values less than 0.05.