Time-dependent exposure after GW33
N
PE
Person weeks
Rate (per 1000/week)
Crude HR (95% CI) Adjusted HR (95% CI)a
Calcium-based antacids
No use 7,897 187 41,539 4.5 Reference Reference
Any use 1,170 21 5,078 4.1 0.9 (0.6-1.4) 1.0 (0.6-1.5)
Low dose (<1 g/day) 589 8 2,252 3.6 0.8 (0.4-1.6) 0.8 (0.4-1.6)
High dose (≥1 g/day) 630 13 2,826 4.6 1.0 (0.6-1.8) 1.1 (0.6-1.9)
Proton pump inhibitors
No use 9,008 216 48,594 4.4 Reference Reference
Any use 267 8 1,168 6.8 1.6 (0.8-3.2) 1.4 (0.7-2.9)
Low dose (≤1 DDD/day) 217 5 918 5.4 1.3 (0.5-3.0) 1.2 (0.5-2.9)
High dose (>1 DDD/day) 55 3 250 12.0 2.7 (0.9-8.5) N/A