3.4. The ratio of OVM-specific IgE to OVM-IgD predicts outgrowing egg allergy.
The ratio of OVM-specific IgE to OVM-specific IgD or IgG4 in the CAE group was significantly higher compared to the PAE, OGE, and NEA groups (Figure 3). Receiver operating analysis revealed that the ratio of OVM-specific IgE to OVM-specific IgD discriminated non-tolerant from partially-tolerant egg-allergic patients with the largest area under the curve (AUC = 0.965) compared with levels of OVM-specific IgE or the ratio of OVM-specific IgE to OVM-specific Ig IgG4 (Figure 4, Table 2). Thus, the ratio of OVM-specific IgE to OVM-specific IgD is the most useful marker to identify high-risk egg allergic patients. The optimal cutoff for the ratio of OVM-specific IgE to OVM-specific IgD had 86.5% sensitivity and 96.4% specificity to identify high-risk subjects (Table 2).