3.4. The ratio of OVM-specific IgE to OVM-IgD predicts
outgrowing egg allergy.
The ratio of OVM-specific IgE to OVM-specific IgD or IgG4 in the CAE
group was significantly higher compared to the PAE, OGE, and NEA groups
(Figure 3). Receiver operating analysis revealed that the ratio of
OVM-specific IgE to OVM-specific IgD discriminated non-tolerant from
partially-tolerant egg-allergic patients with the largest area under the
curve (AUC = 0.965) compared with levels of OVM-specific IgE or the
ratio of OVM-specific IgE to OVM-specific Ig IgG4 (Figure 4, Table 2).
Thus, the ratio of OVM-specific IgE to OVM-specific IgD is the most
useful marker to identify high-risk egg allergic patients. The optimal
cutoff for the ratio of OVM-specific IgE to OVM-specific IgD had 86.5%
sensitivity and 96.4% specificity to identify high-risk subjects (Table
2).