3.3. The relative levels of allergen-specific IgD but not IgG4 depend on the status of egg allergy
The relative levels of OVM-specific IgD were lower than those of OVA-specific IgD in the CAE groups (Fig 2A). In contrast, the relative levels of OVM-specific IgD were similar to levels of OVM-specific IgD in the PAE and OGE groups (Fig 2B and 2C). The relative levels of OVM-specific IgG4 and OVA-specific IgG4 did not differ between the groups (Fig. 2E-H). Therefore, the ratio of OVM-specific IgD to OVA-specific IgD increase as children outgrow egg allergy, whereas the ratio of OVM-specific IgG4 to OVA-specific IgG4 did not change (Fig 2I and 2J).