Temporal patterns of TLR3 variation on Cousin
In the adult population on Cousin, the frequency of the minorTLR3 C allele decreased significantly over time
from 0.40 in 1993 to 0.29 in 2018, with a corresponding increase in theTLR3 A allele (LM: R2 = 0.85,
F1,24 = 140, P <0.001, Fig 1).
Likewise, the minor TLR3 C allele also
significantly decreased over time in the juvenile population (LM:
R2 = 0.68, F1,12 = 28.7, P<0.001, Fig 1).