INTRODUCTION:
According to the extent of widespread epidermal detachment, SJS/TEN is
classified as SJS, SJS/TEN overlap, and TEN with less than 10%, 10%‒
30%, and 30% of body surface area, respectively. The majority of cases
of SJS/TEN are the results of a hypersensitive reaction to a drug, and
the drugs most commonly associated with the diseases are
anticonvulsants, sulfonamide antibiotics, antiretrovirals, non-steroidal
anti-inflammatory drugs (NSAIDs), allopurinol, and corticosteroids
[1-4]. The potential association of anticancer agents with SJS/TEN
has not been systematically investigated and has been inconsistently
reported. Daunorubicin is an anthracycline antibiotic that has
antineoplastic activity and is used in the therapy of acute leukemia and
AIDS related Kaposi sarcoma. [5] Cutaneous side- effects of
Daunorubicin are very rare. In this report, we describe a fatal case of
a 2 years old boy with Precursor B Cell Acute Lymphoblastic Leukaemia
who developed SJS owing to Daunorubicin.
Key words: Steven-Johnson Syndrome/ Toxic Epidermal Necrolysis,
chemotherapy, Daunorubicin, hypersensiticvity reaction