INTRODUCTION:
According to the extent of widespread epidermal detachment, SJS/TEN is classified as SJS, SJS/TEN overlap, and TEN with less than 10%, 10%‒ 30%, and 30% of body surface area, respectively. The majority of cases of SJS/TEN are the results of a hypersensitive reaction to a drug, and the drugs most commonly associated with the diseases are anticonvulsants, sulfonamide antibiotics, antiretrovirals, non-steroidal anti-inflammatory drugs (NSAIDs), allopurinol, and corticosteroids [1-4]. The potential association of anticancer agents with SJS/TEN has not been systematically investigated and has been inconsistently reported. Daunorubicin is an anthracycline antibiotic that has antineoplastic activity and is used in the therapy of acute leukemia and AIDS related Kaposi sarcoma. [5] Cutaneous side- effects of Daunorubicin are very rare. In this report, we describe a fatal case of a 2 years old boy with Precursor B Cell Acute Lymphoblastic Leukaemia who developed SJS owing to Daunorubicin.
Key words: Steven-Johnson Syndrome/ Toxic Epidermal Necrolysis, chemotherapy, Daunorubicin, hypersensiticvity reaction