Abstract:
SARS-CoV-2 infections have presented with numerous neurological manifestations, providing insight into the potential of SARS-CoV-2 virus in triggering autoantibody production and dysregulating the immune system. We report the case of a young obese lady, recently discharged after treatment for COVID-19, who later presented with headache and blurred vision, diagnosed to have pseudotumor cerebri and concurrent bilateral optic neuritis. To the best of our knowledge, this is the first case report to establish concurrent intracranial hypertension, anti-MOG syndrome/neuromyelitis optical optica syndrome disorder (NMOSD) and SARS-CoV-2 infection. The accumulative number of reports of COVID-19 patients with demyelinating manifestations such as bilateral optic neuritis with clinical and radiological features of NMOSD/Anti-MOG syndrome delineate that probable neuro-invasion is a reasonable concern that SARS-CoV-2 is an emerging neuropathogen. Further experimental models and research are warranted to better understand how the acute and chronic course of illness in the context of SARS-CoV-2 could further modulate our approach and treatment.