Antibiotics
Obesity is a risk factor for infections, including surgical wound
infections 39–41. It has been shown, that the
increased risk for surgical wound infections is probably due to the
decreased penetration of the prophylactic antibiotic cefazolin into the
subcutaneous tissue as a result of reduced blood flow to fatty tissue,
as similar plasma concentrations but reduced subcutaneous tissue
concentrations were found 42. Similar reduced
penetration into subcutaneous tissue and muscle was reported for
ciprofloxacin 43. With most studies evaluating
concentrations in plasma, from these results it seems that potentially
reduced perfusion into the target tissue should be considered when
deciding what drug or dose to give after bariatric surgery.