Antibiotics
Obesity is a risk factor for infections, including surgical wound infections 39–41. It has been shown, that the increased risk for surgical wound infections is probably due to the decreased penetration of the prophylactic antibiotic cefazolin into the subcutaneous tissue as a result of reduced blood flow to fatty tissue, as similar plasma concentrations but reduced subcutaneous tissue concentrations were found 42. Similar reduced penetration into subcutaneous tissue and muscle was reported for ciprofloxacin 43. With most studies evaluating concentrations in plasma, from these results it seems that potentially reduced perfusion into the target tissue should be considered when deciding what drug or dose to give after bariatric surgery.