Conflict of Interest Statement:
The Generation R Study is conducted by Erasmus MC University Medical Center Rotterdam in close collaboration with the School of Law and Faculty of Social Sciences of Erasmus University Rotterdam, the Municipal Health Service Rotterdam Metropolitan Area, the Rotterdam Homecare Foundation, and the Stichting Trombosedienst & Artsenlaboratorium Rijnmond. The Dept Immunology of the Erasmus MC funded the immunological measurements. LD received funding from the European Union’s Horizon 2020 research and innovation programme (LIFECYCLE, grant agreement No 733206, 2016; EUCAN-Connect grant agreement No 824989; ATHLETE, grant agreement No 874583). MCvZ is supported by the Australian National Health and Medical Research Council (NHMRC, Senior Research Fellowship 1117687). All authors declare that no competing interests exist. The Department of Dermatology of the Erasmus MC University Medical Center Rotterdam received an unrestricted grant from Micreos Human Health, the Netherlands.