REFERENCES
1. Irvine AD, McLean WH, Leung DY. Filaggrin mutations associated with
skin and allergic diseases. N Engl J Med. 2011;365(14):1315-1327.
2. Sandilands A, Sutherland C, Irvine AD, McLean WH. Filaggrin in the
frontline: role in skin barrier function and disease. J Cell Sci.2009;122(Pt 9):1285-1294.
3. Thyssen JP, Elias PM. It Remains Unknown Whether Filaggrin Gene
Mutations Evolved to Increase Cutaneous Synthesis of Vitamin D.Genome Biol Evol. 2017;9(4):900-901.
4. Goleva E, Berdyshev E, Leung DY. Epithelial barrier repair and
prevention of allergy. J Clin Invest. 2019;129(4):1463-1474.
5. McAleer MA, Irvine AD. The multifunctional role of filaggrin in
allergic skin disease. J Allergy Clin Immunol.2013;131(2):280-291.
6. Rodriguez E, Baurecht H, Herberich E, et al. Meta-analysis of
filaggrin polymorphisms in eczema and asthma: robust risk factors in
atopic disease. J Allergy Clin Immunol. 2009;123(6):1361-1370
e1367.
7. Brown SJ, Asai Y, Cordell HJ, et al. Loss-of-function variants in the
filaggrin gene are a significant risk factor for peanut allergy. J
Allergy Clin Immunol. 2011;127(3):661-667.
8. Rice NE, Patel BD, Lang IA, et al. Filaggrin gene mutations are
associated with asthma and eczema in later life. J Allergy Clin
Immunol. 2008;122(4):834-836.
9. Chan A, Terry W, Zhang H, et al. Filaggrin mutations increase
allergic airway disease in childhood and adolescence through
interactions with eczema and aeroallergen sensitization. Clin Exp
Allergy. 2018;48(2):147-155.
10. Jee MH, Johansen JD, Buus TB, et al. Increased Production of
IL-17A-Producing gammadelta T Cells in the Thymus of Filaggrin-Deficient
Mice. Front Immunol. 2018;9:988.
11. Moosbrugger-Martinz V, Gruber R, Ladstatter K, et al. Filaggrin null
mutations are associated with altered circulating Tregs in atopic
dermatitis. J Cell Mol Med. 2019;23(2):1288-1299.
12. Bonefeld CM, Petersen TH, Bandier J, et al. Epidermal filaggrin
deficiency mediates increased systemic T-helper 17 immune response.Br J Dermatol. 2016;175(4):706-712.
13. Czarnowicki T, Esaki H, Gonzalez J, et al. Alterations in B-cell
subsets in pediatric patients with early atopic dermatitis. J
Allergy Clin Immunol. 2017;140(1):134-144 e139.
14. Czarnowicki T, Gonzalez J, Bonifacio KM, et al. Diverse activation
and differentiation of multiple B-cell subsets in patients with atopic
dermatitis but not in patients with psoriasis. J Allergy Clin
Immunol. 2016;137(1):118-129 e115.
15. Heeringa JJ, Hajdarbegovic E, Thio HB, van Zelm MC. Systemic B-cell
abnormalities in patients with atopic dermatitis? J Allergy Clin
Immunol. 2016;138(1):317-318.
16. Looman KIM, van Meel ER, Grosserichter-Wagener C, et al.
Associations of Th2, Th17, Treg cells, and IgA(+) memory B cells with
atopic disease in children: The Generation R Study. Allergy.2020;75(1):178-187.
17. Kooijman MN, Kruithof CJ, van Duijn CM, et al. The Generation R
Study: design and cohort update 2017. Eur J Epidemiol.2016;31(12):1243-1264.
18. Medina-Gomez C, Felix JF, Estrada K, et al. Challenges in conducting
genome-wide association studies in highly admixed multi-ethnic
populations: the Generation R Study. Eur J Epidemiol.2015;30(4):317-330.
19. Elbert NJ, Duijts L, den Dekker HT, et al. Role of environmental
exposures and filaggrin mutations on associations of ethnic origin with
risk of childhood eczema. The Generation R Study. Pediatr Allergy
Immunol. 2016;27(6):627-635.
20. Kezic S, O’Regan GM, Yau N, et al. Levels of filaggrin degradation
products are influenced by both filaggrin genotype and atopic dermatitis
severity. Allergy. 2011;66(7):934-940.
21. Appay V, van Lier RA, Sallusto F, Roederer M. Phenotype and function
of human T lymphocyte subsets: consensus and issues. Cytometry A.2008;73(11):975-983.
22. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets
of memory T lymphocytes with distinct homing potentials and effector
functions. Nature. 1999;401(6754):708-712.
23. Wallmeyer L, Dietert K, Sochorova M, et al. TSLP is a direct trigger
for T cell migration in filaggrin-deficient skin equivalents. Sci
Rep. 2017;7(1):774.
24. Eyerich K, Eyerich S. Th22 cells in allergic disease. Allergo
J Int. 2015;24(1):1-7.
25. Fujita H. The role of IL-22 and Th22 cells in human skin diseases.J Dermatol Sci. 2013;72(1):3-8.
26. Czarnowicki T, He H, Krueger JG, Guttman-Yassky E. Atopic dermatitis
endotypes and implications for targeted therapeutics. J Allergy
Clin Immunol. 2019;143(1):1-11.
27. Jiao Q, Qian Q, Liu C, et al. T helper 22 cells from Han Chinese
patients with atopic dermatitis exhibit high expression of inducible
T-cell costimulator. Br J Dermatol. 2020;182(3):648-657.
28. Chang J, Mitra N, Hoffstad O, Margolis DJ. Association of Filaggrin
Loss of Function and Thymic Stromal Lymphopoietin Variation With
Treatment Use in Pediatric Atopic Dermatitis. JAMA Dermatol.2017;153(3):275-281.
29. Tsilingiri K, Fornasa G, Rescigno M. Thymic Stromal Lymphopoietin:
To Cut a Long Story Short. Cell Mol Gastroenterol Hepatol.2017;3(2):174-182.
30. van Leersum FS, Nagtzaam IF, van Oosterhoud CN, et al. Improving the
diagnostic yield for filaggrin; concealed mutations in the Dutch
population. J Allergy Clin Immunol. 2020;145(6):1704-1706 e1702.