KEYS MESSAGE
This study in a general pediatric population showed that filaggrin
haploinsufficiency is associated with higher Th22, but not with other B-
and T-cell subsets. FLG mutations did not affect immune cell
composition in a subset of children with AD. Therefore, FLG mutations
pose a risk to allergy development, but do not directly affect or
confound immune measurements in children with atopic
dermatitis.