Total population Total population Total population Total population Sensitivity analyses
Child characteristics
Total (n=523)
Wildtype population (n=479)
FLG mutation population (n=44)
P-value
Missing in total study population (N, %)
Atopic dermatitis (n=102)
Sex (N, %) 1.0 0.0
Female 280 (53.5) 256 (53.4) 24 (54.5) 48 (47.1)
Male 243 (46.5) 223 (46.6) 20 (45.5) 54 (52.9)
FLG mutations (N, %)
0.0
Wildtype 479 (91.6) 479 (100.0) 86 (84.3)
1 or more mutations
44 (8.4) †
44 (100.0)
16 (15.7)
Type FLG mutations (N, %)
S1085CfsX36 (rs41370446)
22 (4.2)
22 (4.2)
0.0
7 (6.9)
R2447X (rs138726443)
6 (1.1)
6 (1.1)
0.2
1 (1.0)
R501X (rs61816761)
18 (3.5)2
18 (3.5)2
0.4
9 (9.0) ‡
S3247X (rs150597413)
0 (0.0)
0 (0.0)
0.4
0 (0.0)
Ever physician diagnosed atopic dermatitis (N, %)§ 102 (22.2) 86 (20.4) 16 (42.1) 0.004 12.0 102 (100.0)
Table 1 represents the child and maternal characteristics for the study population stratified for FLG mutations. Values are based on the non-imputed dataset and represented as number (%). Chi-squared tests were conducted to examine possible differences in baseline characteristics between the different genotypes. Abbreviations: FLG, filaggrin gene; N, number; † Including 3 biallelic mutations (2 compound heterozygous and 1 homozygous) Including one biallelic mutations (homozygous) § Based on parental‐reported questionnaires obtained at the child’s age of 10 years: ever atopic dermatitis (no or yes) Table 1 represents the child and maternal characteristics for the study population stratified for FLG mutations. Values are based on the non-imputed dataset and represented as number (%). Chi-squared tests were conducted to examine possible differences in baseline characteristics between the different genotypes. Abbreviations: FLG, filaggrin gene; N, number; † Including 3 biallelic mutations (2 compound heterozygous and 1 homozygous) Including one biallelic mutations (homozygous) § Based on parental‐reported questionnaires obtained at the child’s age of 10 years: ever atopic dermatitis (no or yes) Table 1 represents the child and maternal characteristics for the study population stratified for FLG mutations. Values are based on the non-imputed dataset and represented as number (%). Chi-squared tests were conducted to examine possible differences in baseline characteristics between the different genotypes. Abbreviations: FLG, filaggrin gene; N, number; † Including 3 biallelic mutations (2 compound heterozygous and 1 homozygous) Including one biallelic mutations (homozygous) § Based on parental‐reported questionnaires obtained at the child’s age of 10 years: ever atopic dermatitis (no or yes) Table 1 represents the child and maternal characteristics for the study population stratified for FLG mutations. Values are based on the non-imputed dataset and represented as number (%). Chi-squared tests were conducted to examine possible differences in baseline characteristics between the different genotypes. Abbreviations: FLG, filaggrin gene; N, number; † Including 3 biallelic mutations (2 compound heterozygous and 1 homozygous) Including one biallelic mutations (homozygous) § Based on parental‐reported questionnaires obtained at the child’s age of 10 years: ever atopic dermatitis (no or yes) Table 1 represents the child and maternal characteristics for the study population stratified for FLG mutations. Values are based on the non-imputed dataset and represented as number (%). Chi-squared tests were conducted to examine possible differences in baseline characteristics between the different genotypes. Abbreviations: FLG, filaggrin gene; N, number; † Including 3 biallelic mutations (2 compound heterozygous and 1 homozygous) Including one biallelic mutations (homozygous) § Based on parental‐reported questionnaires obtained at the child’s age of 10 years: ever atopic dermatitis (no or yes) Table 1 represents the child and maternal characteristics for the study population stratified for FLG mutations. Values are based on the non-imputed dataset and represented as number (%). Chi-squared tests were conducted to examine possible differences in baseline characteristics between the different genotypes. Abbreviations: FLG, filaggrin gene; N, number; † Including 3 biallelic mutations (2 compound heterozygous and 1 homozygous) Including one biallelic mutations (homozygous) § Based on parental‐reported questionnaires obtained at the child’s age of 10 years: ever atopic dermatitis (no or yes) Table 1 represents the child and maternal characteristics for the study population stratified for FLG mutations. Values are based on the non-imputed dataset and represented as number (%). Chi-squared tests were conducted to examine possible differences in baseline characteristics between the different genotypes. Abbreviations: FLG, filaggrin gene; N, number; † Including 3 biallelic mutations (2 compound heterozygous and 1 homozygous) Including one biallelic mutations (homozygous) § Based on parental‐reported questionnaires obtained at the child’s age of 10 years: ever atopic dermatitis (no or yes)