DISCUSSION
In this population-based study among children of European genetic
ancestry, we observed a prevalence of 8.4% for FLG mutations. In
addition, we demonstrated that children with FLG mutations had
higher Th22 cell numbers than children without FLG mutations. In
contrast, the Th1, Th2, Th17, Treg and memory B cell numbers were
comparable between children with and without FLG mutations. In
addition, among children with AD, those with or without FLGmutations had no differences in B or T cell subsets.