Results
Percentages of CD3+, CD4+ and CD8+ T cells were similar among groups. We
identified five subpopulations of CD8+ and seven of CD4+ cells. The
CD4+Tbet+CD45RO+ cells identified in the unsupervised analysis were
significantly increased in PR-SLE vs Act-SLE (median: 10.20, IQR:
1.74-30.50 vs. 1.68, IQR: 0.4-2.83; p<0.01). CD4+EOMES+ cells
were also increased in PR-SLE vs Act-SLE (5.24, IQR: 3.38-14.70 vs.
1.39, IQR: 0.48-2.87; p<0.001). CD8+ EOMES+ cells were
increased in PR-SLE vs Act-SLE (37.6, IQR: 24.9-53.2 vs 8.13, IQR:
2.33-20.5; p<0.001). Exhausted and activated T cells presented
an increased frequency of PD-1, CD57 and EOMES in SLE patients vs
healthy subjects.