Methods
We included 15 PR-SLE patients, 15 Act-SLE and 29 healthy subjects.
T-cell exhaustion was determined by flow cytometry according to the
expression of PD-1, Tim-3, 2B4, EOMES and T-bet in CD4+ and CD8+ T
cells. Dimensionality reduction using the t-Distributed Stochastic
Neighbor Embedding algorithm and Clustering Analysis was used for the
identification of relevant populations.