Recruitment
Due to the rapidly evolving pandemic situation, we have a strong
uncertainty about the pace of enrolment. There is likely to be
considerable variation in the number of COVID-19 infections requiring
hospitalisation in different regions. The pragmatic pre-specified pooled
analysis design overcomes recruitment difficulties that could occur in
the individual studies given the international dynamics of the COVID-19
pandemic.
Research coordinators and investigators at each site and for each study
will work with clinicians to identify potential candidates for
enrolment. Logs will be maintained of patients who met the inclusion
criteria but were not enrolled, with the reason for exclusion recorded
on the log.