Platelet mass index and tinnitus
Abstract:
Although there is plenty of research on the etiology and treatment of tinnitus, a definitive conclusion has not been reached in most studies. Among etiological factors, vascular and hematological abnormalities can be defined as an important cause in the evaluation of tinnitus cases, and these factors may underly many structural and functional problems. In this study, we aimed to investigate whether there was a correlation between platelet mass index (PMI) and tinnitus. To our knowledge, this is the first study exploring the effect of platelet mass on tinnitus.
After reviewing the detailed medical records (examination notes, drug use, radiological evaluations, audiological evaluations, and previous surgical procedures) of 1,079 tinnitus patients that presented to our clinic between January 2019 and May 2020, the hemogram values of 177 cases meeting the study criteria were evaluated. Age, gender, hemoglobin, neutrophil, lymphocyte, platelet, and mean platelet volume (MPV) were examined. This was followed by the assessment of the distributions of age, gender, hemoglobin level, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and PMI.
There was no statistically significant difference between the patient and control groups in terms of mean age, gender distribution, and RBC (Red Blood Cell) , neutrophil, lymphocyte, PLR and NLR levels (p>0.05). Compared to the control group, the hemoglobin and MPV levels of the patient group were statistically significantly higher (p<0.001), and the platelet level was statistically significantly lower (p=0.033). In addition, the PMI level of the patient group was significantly higher than that of the control group (p<0.001).
In conclusion, the NLR, PLR and MPV values were found to be higher in the tinnitus group compared to the control group, as expected. Furthermore, the additional data for tinnitus cases showed that PMI was also observed to be significantly higher compared to the control group, indicating that the study objective was reached. PMI seems to be a predictive value for tinnitus, even in patients with MPV values lower than the normal range. Therefore, we consider that PMI is more sensitive than other markers, especially MPV in inflammatory events.
Key words: Tinnitus, Platelet Mass Index, NLR, PLR, MPV
What’s already known about this topic?
-mpv is a inflamatory marker. And there are some study about this subject. also hematological parameters have an important place in tinnitus etiology. Here we studied the most sensitive marker among all hematological data in this study.
What does this article add?
- 1- PMI is a more sensitive indicator than MPV
- A cutt off value is set for PMI
- Can show a way to treat tinnitus
Review criteria: how did you gather, select and analyze the information you considered in your review?
-Medical records of all patients diagnosed with tinnitus was retrospectively reviewed.
-we excluded all diseases that cause tinnitus.
Message for the clinic: what is the ‘take-home’ message for the clinician?
-The function and number of platelets are as important as the volume.
- PMI can express them all together.
-PMI is the parameter that most clearly demonstrates the role of platelets in tinnitus.