Gene Drugs with
required PGx-testing1 Drugs with
recommended PGx-testing1 Drugs with
actionable PGx-testing1 n (%) Patients with phenotype variants2
ABCB1 - - - 106 (78.5)4
CYP2C9 siponimod - celecoxib, phenytoin, warfarin 46 (34)
CYP2C19 - atazanavir amitriptyline, carisoprodol, citalopram, clobazam, clomipramine, clopidogrel, desipramine, doxepin, imipramine, nortriptyline, pantoprazole, trimipramine, voriconazole 71 (52)
CYP2D6 pimozide, tetrabenazine - amitriptyline, aripiprazole, atomoxetine, brexpiprazole, carvedilol, cevimeline, citalopram, clomipramine, clozapine, codeine, darifenacin, desipramine, doxepin, fesoterodine, iloperodine, nortriptyline, perphenazine, propafenone, tamoxifen, thioridazine, tramadol, trimipramine, vortioxetine 67 (50)
SLCO1B13 - - - 30 (22)
VKORC1 - - warfarin 86 (63.7)
COMT - - - 73 (54.1)
CYP1A2 - - - 65 (48.6)
CYP2B6 - - efavirenz 67 (49.6)
CYP3A4 - - codeine, tamoxifen 6 (4.4)
CYP3A5 - - - 17 (12.6)
CYP4F2 - - warfarin 66 (48,9)4
DPYD - - capecitabin, fluorouracil 5 (3.7)
OPRM1 - - codeine 34 (25.2)
POR - - - 72 (53.3)4
TPMT - azathioprine, mercaptopurine tioguanine 8 (5.9)