Cross-reactivity between Polybia and other wasps:
Polybia paulista venom contains Phospholipase A1 (PLA1), hyaluronidase, antigen 5, and dipeptidyl peptidase IV as well as large amounts of serine proteases (Table 4).48 PLA1 and antigen 5 from Polybia are more similar to that fromPolistes (~80% SI) than to that fromVespula (~60% SI).
Polybia PLA1 (Poly p 1) has been found to be strongly cross-reactive with PLA1 from Polistes , but not with fire ant,Vespula, and honey bee venom.49 In contrast, for antigen 5, substantial cross-reactivity has also been reported withVespula. 50 Polybia paulistahyaluronidase strongly cross-reacts with Polistes hyaluronidase (~95% SI) but not with honey bee Api m 2 and fire ant venom (~50% SI).51 Polybiavenom reportedly lacks cross-reactive carbohydrate determinants (CCDs) and does not exhibit diagnostic interference as do Vespinaevenoms.52-54