FIGURE LEGENDS
Figure 1 . Study Flow Diagram.
Figure 2. Risk of Bias Summary. Each study included in
the meta-analysis was assessed for risk of bias based on whether the
various measures as shown in the figure were satisfied. Question marks
within yellow circles indicate that it was not clear whether the study
satisfied the measure. Plus signs within green circles indicate that the
study satisfied the measure. Minus signs within red circles indicate
that the study did not satisfy the measure. The EPPIC-1 and EPPIC-2
trials were combined under “Schulman 2015” as shown in the figure.
Figure 3. Comparison of the Effect of AST-120 versus
Control on All-cause Mortality.
Figure 4. Comparison of the Effect of AST-120 versus
Control on the Incidence of End-stage Renal Disease Requiring Renal
Replacement Therapy.
Figure 5. Comparison of the Effect of AST-120 versus
Control on Serum Creatinine Levels.
Table 1 Characteristics of Studies Included in the Meta-analysis