Importance and Implications
Currently, the use of AST-120 in the management of CKD is not yet
included in clinical practice guidelines due to the paucity of
large-scale trials. The most recent systematic reviews and meta-analyses
are based on several small studies with a relatively small population
size. With the recent publication of three large clinical trials, namely
EPPIC-1, EPPIC-2, and K-STAR, there was a need to consolidate evidence
regarding the efficacy of AST-120 in preventing progression of CKD.