The EGFR receptor protein has different domains with different key signaling roles \cite{Ferguson2008}. As a result, mutations in the gene expressing them also manifest uniquely in different cancers. For example, mutations in the tyrosine kinase domain are unique to lung cancers \cite{Purba2017}\cite{Lee2010} while brain tumors show mutations in the autoregulatory domains and the ectodomains of the same gene \cite{Wong1987}\cite{Binder2018}.