Further food antigen-specific T-cells are increased in active
disease with ileal inflammation
To dissect a sole barrier defect, as it is present in small intestinal
CD, from the disease-driving gliadin-reactivity in CeD, we included
soybean protein, peanut protein and OVA-peptide in our analysis. In
fact, an increased frequency of antigen-specific CD4+T-cells was exclusively observed in the presence of small intestinal
inflammation, namely CD and aCeD. CD patients in remission as well as UC
patients independent of their inflammatory state did not differ from
healthy controls. Furthermore, CeD patients on GFD, although being
highly reactive to gliadin, showed no reaction to other nutritional
antigens (FigureĀ 3A, B ).