Demographic and characteristics
Based on the original data, some data were excluded due to various kinds
of reasons as follows. Firstly, we only counted clear and hierarchical
color of amniotic fluid. Therefore, pink, bloody, and brown amniotic
fluid was excluded. Then, for oxytocic manner, only parturients managed
with one mode were recorded to shrug off the effect of interaction
between disposing approaches. Besides, parturients over 2 births were
excluded because of twins existing
Demographic and characteristics for all maternity and newborn
During the whole of 2018, 1797 women in labor suffered from the
intrapartum fever in the hospital, and 2850 matched afebrile parturients
were also enrolled in this study. And the proportion of the maximum
temperature in fever group from 37.5 ℃ to 38.0 ℃, 38.0 ℃ to 38.5 ℃, and
over 38.5 ℃ was 34.60%, 53.09%, and 12.31%, respectively (Figure S1).
Table 1 displays the obstetrical characteristics of all included
maternity and newborn data and the results demonstrated that the
difference between intrapartum fever and afebrile groups exists in
maternal age, gestational weeks at delivery, gravidity and parity, the
turbidity of the amniotic fluid, birth weight of the newborn, degree of
perineal laceration, oxytocic manner, time of the first and the second
stage of labor. The maternity age in the study group was 28.41 ± 2.55,
and up to 29.34 ± 2.82 in afebrile group (P < 0.0001).
And the gestational weeks in intrapartum fever and afebrile group were
39.74 ± 1.59 and 39.48 ± 2.61 (P < 0.0001),
respectively. The febrile subjects had lower gravidity and parity,
especially for parity. Nearly 95% febrile parturients were nulliparous
cases, but less than 69% nulliparous women in afebrile group. As for
oxytocic manner during delivery, oxytocin regimens represented two
thirds in fever mother-to-be women, nevertheless, more than 60%
parturients without any managements in afebrile group (P< 0.0001). Besides, more bleeding (307.58 ± 96.25 vs. 283.25 ±
51.60, P < 0.0001) and cloudy amniotic fluid (31.72%
vs. 18.21%, P < 0.0001) occurred in fever group,
whereas they were less prone to bear the laceration of perineum (73.57%
vs. 86.21%, P < 0.0001). Moreover, in intrapartum
fever group, the newborn birth weight was a little higher (3384.15 ±
376.79 g vs. 3299.30 ± 442.05 g, P < 0.0001), and the
first (632.13 ± 167.137 min vs. 417.76 ± 240.92 min, P< 0.0001) and the second (36.07 ± 17.47 min vs. 28.99 ±16.28
min, P < 0.0001) stage of labor were all longer than
the afebrile group. However, the third stage of labor in these two
groups had no significant difference. We additionally calculated the
labor time after fever between 37.5 ℃ and 38.0 ℃, 38.0℃ and 38.5 ℃, and
over 38.5 ℃, and the corresponding results were 256 min, 242 min, and
199 min (Figure S2). Similar to the third stage of labor, the volume of
amniotic fluid also showed no significant difference.
Demographic and characteristics for nulliparity and corresponding
newborn
For the sake of reducing the impact of the parity, we drew the situation
of nulliparity alone (Table 2). After included nulliparity only, the
number of parturients in intrapartum fever and afebrile group reduced by
91 (1797 to 1706) and 892 (2850 to 1958), respectively. Afebrile
maternal age was above the fever parturients before grouping, yet
decreased from 29.34 ± 3.85 to
28.00 ± 2.82 and below the febrile
group (P = 0.005). In fever and afebrile group, the total, the
first, and the second stage of labor time were all extended and the
difference (P < 0.0001) still remained, especially for
total labor time (from 455.92 ± 248.43 min to 530.27 ± 239.14 min,P < 0.0001) and the first stage of labor in afebrile
maternity (from 417.76 ± 240.92 min to 487.22 ± 233.33 min, P< 0.0001). Moreover, the gravidity in afebrile group was more
frequent (P < 0.0001) but had no significant difference
between the two groups in nulliparity (P = 0.411).
For neonatal data, the weight difference of newborns became larger due
to the birth weight in fever group unchanged nearly (from 3384.15 ±
376.79 g to 3382.86 ± 371.97 g), nonetheless, declined to 3264.99 ±
427.58 g from 3299.30 ± 442.05 g in afebrile group.
Other variables, including gestational weeks, oxytocic manner, the
volume of intrapartum hemorrhage, amniotic fluid turbidity, and the
degree of perineal laceration, all of the above altered not notably in
both groups after grouping. Besides, the volume of amniotic fluid
(P = 0.924) and the third stage of labor (P = 0.539) still
showed no striking difference in two types of population.